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Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review

Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development. Although the knowledge of these disciplines is essential, they have historically been treated se...

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Autores principales: Pereira, Laiz Campos, de Fátima, Marcelo Aguiar, Santos, Valdeene Vieira, Brandão, Carolina Magalhães, Alves, Izabel Almeida, Azeredo, Francine Johansson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330032/
https://www.ncbi.nlm.nih.gov/pubmed/35892376
http://dx.doi.org/10.3390/antibiotics11080986
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author Pereira, Laiz Campos
de Fátima, Marcelo Aguiar
Santos, Valdeene Vieira
Brandão, Carolina Magalhães
Alves, Izabel Almeida
Azeredo, Francine Johansson
author_facet Pereira, Laiz Campos
de Fátima, Marcelo Aguiar
Santos, Valdeene Vieira
Brandão, Carolina Magalhães
Alves, Izabel Almeida
Azeredo, Francine Johansson
author_sort Pereira, Laiz Campos
collection PubMed
description Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development. Although the knowledge of these disciplines is essential, they have historically been treated separately. While pharmacokinetics was limited to describing the time course of plasma concentrations after administering a drug-dose, pharmacodynamics describes the intensity of the response to these concentrations. In the last decades, the concept of pharmacokinetic/pharmacodynamic modeling (PK/PD) emerged, which seeks to establish mathematical models to describe the complete time course of the dose-response relationship. The integration of these two fields has had applications in optimizing dose regimens in treating antibacterial and antifungals. The anti-infective PK/PD models predict the relationship between different dosing regimens and their pharmacological activity. The reviewed studies show that PK/PD modeling is an essential and efficient tool for a better understanding of the pharmacological activity of antibacterial and antifungal agents.
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spelling pubmed-93300322022-07-29 Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review Pereira, Laiz Campos de Fátima, Marcelo Aguiar Santos, Valdeene Vieira Brandão, Carolina Magalhães Alves, Izabel Almeida Azeredo, Francine Johansson Antibiotics (Basel) Review Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development. Although the knowledge of these disciplines is essential, they have historically been treated separately. While pharmacokinetics was limited to describing the time course of plasma concentrations after administering a drug-dose, pharmacodynamics describes the intensity of the response to these concentrations. In the last decades, the concept of pharmacokinetic/pharmacodynamic modeling (PK/PD) emerged, which seeks to establish mathematical models to describe the complete time course of the dose-response relationship. The integration of these two fields has had applications in optimizing dose regimens in treating antibacterial and antifungals. The anti-infective PK/PD models predict the relationship between different dosing regimens and their pharmacological activity. The reviewed studies show that PK/PD modeling is an essential and efficient tool for a better understanding of the pharmacological activity of antibacterial and antifungal agents. MDPI 2022-07-22 /pmc/articles/PMC9330032/ /pubmed/35892376 http://dx.doi.org/10.3390/antibiotics11080986 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pereira, Laiz Campos
de Fátima, Marcelo Aguiar
Santos, Valdeene Vieira
Brandão, Carolina Magalhães
Alves, Izabel Almeida
Azeredo, Francine Johansson
Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
title Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
title_full Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
title_fullStr Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
title_full_unstemmed Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
title_short Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
title_sort pharmacokinetic/pharmacodynamic modeling and application in antibacterial and antifungal pharmacotherapy: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330032/
https://www.ncbi.nlm.nih.gov/pubmed/35892376
http://dx.doi.org/10.3390/antibiotics11080986
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