Cargando…
Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study
Background: The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 an...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330065/ https://www.ncbi.nlm.nih.gov/pubmed/35897373 http://dx.doi.org/10.3390/ijerph19159003 |
_version_ | 1784758071998808064 |
---|---|
author | Azatyan, Vahe Yessayan, Lazar Sargsyan, Aelita Khachatryan, Anna Ghevondyan, Tigran Shmavonyan, Melanya Melik-Andreasyan, Gayane Porksheyan, Kristina Manrikyan, Mikael |
author_facet | Azatyan, Vahe Yessayan, Lazar Sargsyan, Aelita Khachatryan, Anna Ghevondyan, Tigran Shmavonyan, Melanya Melik-Andreasyan, Gayane Porksheyan, Kristina Manrikyan, Mikael |
author_sort | Azatyan, Vahe |
collection | PubMed |
description | Background: The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 and ɤ-INF in the oral fluid was determined by ELISA. Buccal mucosa and gums biopsies passed histological examination. An immunohistochemical study of mucous membrane biopsies was performed using monoclonal mouse antibodies to CD3+ and CD20+. Results: The HCV patients group included 96 (63.5% males), and the non-HCV group included 100 subjects (62.0% males) with lesions of the oral mucous membrane. The lesions of lips and oral mucosa were more frequent in HCV than in the non-HCV group—e.g., erosion (13.5% vs. 1%), cracks in the mouth corners (42.7% vs. 0%), changes in the oral mucosa surface (89.6% vs. 3.0%), hemorrhages (78.1% vs. 0%), etc. The pro-inflammatory IL-2 level was higher and anti-inflammatory IL-4 level was lower in HCV patients compared with those in the non-HCV group. Conclusions: Morphological changes developed in the microvasculature both worsen the tissue trophism and accelerate the healing with differentiation into coarse-fibrous connective tissue. Immunohistochemical findings indicated a decrease in local humoral immune response. |
format | Online Article Text |
id | pubmed-9330065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93300652022-07-29 Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study Azatyan, Vahe Yessayan, Lazar Sargsyan, Aelita Khachatryan, Anna Ghevondyan, Tigran Shmavonyan, Melanya Melik-Andreasyan, Gayane Porksheyan, Kristina Manrikyan, Mikael Int J Environ Res Public Health Article Background: The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 and ɤ-INF in the oral fluid was determined by ELISA. Buccal mucosa and gums biopsies passed histological examination. An immunohistochemical study of mucous membrane biopsies was performed using monoclonal mouse antibodies to CD3+ and CD20+. Results: The HCV patients group included 96 (63.5% males), and the non-HCV group included 100 subjects (62.0% males) with lesions of the oral mucous membrane. The lesions of lips and oral mucosa were more frequent in HCV than in the non-HCV group—e.g., erosion (13.5% vs. 1%), cracks in the mouth corners (42.7% vs. 0%), changes in the oral mucosa surface (89.6% vs. 3.0%), hemorrhages (78.1% vs. 0%), etc. The pro-inflammatory IL-2 level was higher and anti-inflammatory IL-4 level was lower in HCV patients compared with those in the non-HCV group. Conclusions: Morphological changes developed in the microvasculature both worsen the tissue trophism and accelerate the healing with differentiation into coarse-fibrous connective tissue. Immunohistochemical findings indicated a decrease in local humoral immune response. MDPI 2022-07-24 /pmc/articles/PMC9330065/ /pubmed/35897373 http://dx.doi.org/10.3390/ijerph19159003 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Azatyan, Vahe Yessayan, Lazar Sargsyan, Aelita Khachatryan, Anna Ghevondyan, Tigran Shmavonyan, Melanya Melik-Andreasyan, Gayane Porksheyan, Kristina Manrikyan, Mikael Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study |
title | Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study |
title_full | Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study |
title_fullStr | Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study |
title_full_unstemmed | Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study |
title_short | Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study |
title_sort | morphological changes in the oral mucous membrane in viral hepatitis c patients: a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330065/ https://www.ncbi.nlm.nih.gov/pubmed/35897373 http://dx.doi.org/10.3390/ijerph19159003 |
work_keys_str_mv | AT azatyanvahe morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT yessayanlazar morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT sargsyanaelita morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT khachatryananna morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT ghevondyantigran morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT shmavonyanmelanya morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT melikandreasyangayane morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT porksheyankristina morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy AT manrikyanmikael morphologicalchangesintheoralmucousmembraneinviralhepatitiscpatientsacrosssectionalstudy |