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Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption

[Image: see text] This article presents new possibilities of using thin films of lanthanide stearates as sorbent materials. Modification of the Q-sense device resonator with monolayers of lanthanide stearates by the Langmuir–Schaeffer method made it possible to study the process of insulin protein a...

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Autores principales: Ladikan, Olga, Silyavka, Elena, Mitrofanov, Andrei, Laptenkova, Anastasia, Shilovskikh, Vladimir, Kolonitckii, Petr, Ivanov, Nikita, Remezov, Andrey, Fedorova, Anna, Khripun, Vassily, Pestova, Olga, Podolskaya, Ekaterina P., Sukhodolov, Nikolai G., Selyutin, Artem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330115/
https://www.ncbi.nlm.nih.gov/pubmed/35910105
http://dx.doi.org/10.1021/acsomega.1c07300
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author Ladikan, Olga
Silyavka, Elena
Mitrofanov, Andrei
Laptenkova, Anastasia
Shilovskikh, Vladimir
Kolonitckii, Petr
Ivanov, Nikita
Remezov, Andrey
Fedorova, Anna
Khripun, Vassily
Pestova, Olga
Podolskaya, Ekaterina P.
Sukhodolov, Nikolai G.
Selyutin, Artem A.
author_facet Ladikan, Olga
Silyavka, Elena
Mitrofanov, Andrei
Laptenkova, Anastasia
Shilovskikh, Vladimir
Kolonitckii, Petr
Ivanov, Nikita
Remezov, Andrey
Fedorova, Anna
Khripun, Vassily
Pestova, Olga
Podolskaya, Ekaterina P.
Sukhodolov, Nikolai G.
Selyutin, Artem A.
author_sort Ladikan, Olga
collection PubMed
description [Image: see text] This article presents new possibilities of using thin films of lanthanide stearates as sorbent materials. Modification of the Q-sense device resonator with monolayers of lanthanide stearates by the Langmuir–Schaeffer method made it possible to study the process of insulin protein adsorption on the surface of new thin-film sorbents. The resulting films were also characterized by compression isotherms, chemical analysis, scanning electron microscopy, and mass spectrometry. The transition of stearic acid to salt was recorded by IR spectroscopy. Using the LDI MS method, the main component of thin films, lanthanide distearate, was established. The presence of Eu(2+) in thin films was revealed. In the case of europium stearate, the maximum value of insulin adsorption was obtained, −1.67·10(−10) mole/cm(2). The findings suggest the possibility of using thin films of lanthanide stearates as a sorption material for the proteomics determination of the quantitative protein content in complex fluid systems by specific adsorption on modified surfaces and isolation of such proteins from complex mixtures.
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spelling pubmed-93301152022-07-29 Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption Ladikan, Olga Silyavka, Elena Mitrofanov, Andrei Laptenkova, Anastasia Shilovskikh, Vladimir Kolonitckii, Petr Ivanov, Nikita Remezov, Andrey Fedorova, Anna Khripun, Vassily Pestova, Olga Podolskaya, Ekaterina P. Sukhodolov, Nikolai G. Selyutin, Artem A. ACS Omega [Image: see text] This article presents new possibilities of using thin films of lanthanide stearates as sorbent materials. Modification of the Q-sense device resonator with monolayers of lanthanide stearates by the Langmuir–Schaeffer method made it possible to study the process of insulin protein adsorption on the surface of new thin-film sorbents. The resulting films were also characterized by compression isotherms, chemical analysis, scanning electron microscopy, and mass spectrometry. The transition of stearic acid to salt was recorded by IR spectroscopy. Using the LDI MS method, the main component of thin films, lanthanide distearate, was established. The presence of Eu(2+) in thin films was revealed. In the case of europium stearate, the maximum value of insulin adsorption was obtained, −1.67·10(−10) mole/cm(2). The findings suggest the possibility of using thin films of lanthanide stearates as a sorption material for the proteomics determination of the quantitative protein content in complex fluid systems by specific adsorption on modified surfaces and isolation of such proteins from complex mixtures. American Chemical Society 2022-07-14 /pmc/articles/PMC9330115/ /pubmed/35910105 http://dx.doi.org/10.1021/acsomega.1c07300 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Ladikan, Olga
Silyavka, Elena
Mitrofanov, Andrei
Laptenkova, Anastasia
Shilovskikh, Vladimir
Kolonitckii, Petr
Ivanov, Nikita
Remezov, Andrey
Fedorova, Anna
Khripun, Vassily
Pestova, Olga
Podolskaya, Ekaterina P.
Sukhodolov, Nikolai G.
Selyutin, Artem A.
Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption
title Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption
title_full Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption
title_fullStr Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption
title_full_unstemmed Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption
title_short Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption
title_sort thin films of lanthanide stearates as modifiers of the q-sense device sensor for studying insulin adsorption
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330115/
https://www.ncbi.nlm.nih.gov/pubmed/35910105
http://dx.doi.org/10.1021/acsomega.1c07300
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