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Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection

Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer’s disease (AD) was shown to be caused by chronic inflammation that may be induced by infection, but the role of pathogenic-bacteria-related AD-associated Aβ is not yet clearly understood. In this study, we validated t...

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Autores principales: Lim, Jung Yeon, Lee, Jung Eun, Kim, Han Kyung, Park, Yeon-Joon, Jeon, Jung Ho, Park, Soon-A., Lee, Naeun, Lee, Il Hwan, Kim, Do Hyun, Yang, Seung Ho, Yoo, Jongman, Kim, Sung Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330135/
https://www.ncbi.nlm.nih.gov/pubmed/35892582
http://dx.doi.org/10.3390/cells11152285
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author Lim, Jung Yeon
Lee, Jung Eun
Kim, Han Kyung
Park, Yeon-Joon
Jeon, Jung Ho
Park, Soon-A.
Lee, Naeun
Lee, Il Hwan
Kim, Do Hyun
Yang, Seung Ho
Yoo, Jongman
Kim, Sung Won
author_facet Lim, Jung Yeon
Lee, Jung Eun
Kim, Han Kyung
Park, Yeon-Joon
Jeon, Jung Ho
Park, Soon-A.
Lee, Naeun
Lee, Il Hwan
Kim, Do Hyun
Yang, Seung Ho
Yoo, Jongman
Kim, Sung Won
author_sort Lim, Jung Yeon
collection PubMed
description Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer’s disease (AD) was shown to be caused by chronic inflammation that may be induced by infection, but the role of pathogenic-bacteria-related AD-associated Aβ is not yet clearly understood. In this study, we validated the hypothesis that there is a correlation between the Aβ-protein load and bacterial infection and that there are effects of bacteria, Staphylococcus aureus (S. aureus), on the Aβ load in the inflammatory environment of human tonsils. Here, we detected Aβ-peptide deposits in human tonsil tissue as well as tissue similar to tonsilloliths found in the olfactory cleft. Interestingly, we demonstrated for the first time the presence of Staphylococcus aureus (S. aureus) clustered around or embedded in the Aβ deposits. Notably, we showed that treatment with S. aureus upregulated the Aβ-protein load in cultures of human tonsil organoids and brain organoids, showing the new role of S. aureus in Aβ-protein aggregation. These findings suggest that a reservoir of Aβ and pathogenic bacteria may be a possible therapeutic target in human tonsils, supporting the treatment of antibiotics to prevent the deposition of Aβ peptides via the removal of pathogens in the intervention of AD pathogenesis.
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spelling pubmed-93301352022-07-29 Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection Lim, Jung Yeon Lee, Jung Eun Kim, Han Kyung Park, Yeon-Joon Jeon, Jung Ho Park, Soon-A. Lee, Naeun Lee, Il Hwan Kim, Do Hyun Yang, Seung Ho Yoo, Jongman Kim, Sung Won Cells Article Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer’s disease (AD) was shown to be caused by chronic inflammation that may be induced by infection, but the role of pathogenic-bacteria-related AD-associated Aβ is not yet clearly understood. In this study, we validated the hypothesis that there is a correlation between the Aβ-protein load and bacterial infection and that there are effects of bacteria, Staphylococcus aureus (S. aureus), on the Aβ load in the inflammatory environment of human tonsils. Here, we detected Aβ-peptide deposits in human tonsil tissue as well as tissue similar to tonsilloliths found in the olfactory cleft. Interestingly, we demonstrated for the first time the presence of Staphylococcus aureus (S. aureus) clustered around or embedded in the Aβ deposits. Notably, we showed that treatment with S. aureus upregulated the Aβ-protein load in cultures of human tonsil organoids and brain organoids, showing the new role of S. aureus in Aβ-protein aggregation. These findings suggest that a reservoir of Aβ and pathogenic bacteria may be a possible therapeutic target in human tonsils, supporting the treatment of antibiotics to prevent the deposition of Aβ peptides via the removal of pathogens in the intervention of AD pathogenesis. MDPI 2022-07-24 /pmc/articles/PMC9330135/ /pubmed/35892582 http://dx.doi.org/10.3390/cells11152285 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lim, Jung Yeon
Lee, Jung Eun
Kim, Han Kyung
Park, Yeon-Joon
Jeon, Jung Ho
Park, Soon-A.
Lee, Naeun
Lee, Il Hwan
Kim, Do Hyun
Yang, Seung Ho
Yoo, Jongman
Kim, Sung Won
Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection
title Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection
title_full Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection
title_fullStr Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection
title_full_unstemmed Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection
title_short Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection
title_sort human palatine tonsils are linked to alzheimer’s disease through function of reservoir of amyloid beta protein associated with bacterial infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330135/
https://www.ncbi.nlm.nih.gov/pubmed/35892582
http://dx.doi.org/10.3390/cells11152285
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