Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest

The occurrence of cisplatin resistance is still the main factor limiting the therapeutic effect of non-small cell lung cancer (NSCLC). It is urgent to elucidate the resistance mechanism and develop novel treatment strategies. Targeted metabolomics was first performed to detect amino acids’ content i...

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Detalles Bibliográficos
Autores principales: Han, Bingjie, Sun, Yuanyuan, Zhang, Xiaofen, Yue, Ping, Tian, Meiling, Yan, Dan, Yin, Fanxiang, Qin, Bo, Zhao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330219/
https://www.ncbi.nlm.nih.gov/pubmed/35910374
http://dx.doi.org/10.3389/fphar.2022.942261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330219/
https://www.ncbi.nlm.nih.gov/pubmed/35910374
http://dx.doi.org/10.3389/fphar.2022.942261

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