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Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1: Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains

[Image: see text] The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP(3), PtdIns(3,4,5)P(3)) independent manner. To understand this new PDK1 regulatory mechanism, doc...

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Detalles Bibliográficos
Autores principales:	Garcia-Viloca, Mireia, Bayascas, Jose Ramón, Lluch, José M., González-Lafont, Àngels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330272/ https://www.ncbi.nlm.nih.gov/pubmed/35910176 http://dx.doi.org/10.1021/acsomega.2c02020

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