Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation

SiO(2)–SO(3)H, with a surface area of 115 m(2)/g and pore volume of 0.38 cm(3)g(−1), and 1.32 mmol H(+)/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min...

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Autores principales: Barbosa, Sandro L., Nelson, David Lee, Freitas, Milton de S., dos Santos, Wallans Torres Pio, Klein, Stanlei I., Clososki, Giuliano C., Caires, Franco J., Wentz, Alexandre P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330306/
https://www.ncbi.nlm.nih.gov/pubmed/35897943
http://dx.doi.org/10.3390/molecules27154767
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author Barbosa, Sandro L.
Nelson, David Lee
Freitas, Milton de S.
dos Santos, Wallans Torres Pio
Klein, Stanlei I.
Clososki, Giuliano C.
Caires, Franco J.
Wentz, Alexandre P.
author_facet Barbosa, Sandro L.
Nelson, David Lee
Freitas, Milton de S.
dos Santos, Wallans Torres Pio
Klein, Stanlei I.
Clososki, Giuliano C.
Caires, Franco J.
Wentz, Alexandre P.
author_sort Barbosa, Sandro L.
collection PubMed
description SiO(2)–SO(3)H, with a surface area of 115 m(2)/g and pore volume of 0.38 cm(3)g(−1), and 1.32 mmol H(+)/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times.
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spelling pubmed-93303062022-07-29 Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation Barbosa, Sandro L. Nelson, David Lee Freitas, Milton de S. dos Santos, Wallans Torres Pio Klein, Stanlei I. Clososki, Giuliano C. Caires, Franco J. Wentz, Alexandre P. Molecules Article SiO(2)–SO(3)H, with a surface area of 115 m(2)/g and pore volume of 0.38 cm(3)g(−1), and 1.32 mmol H(+)/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times. MDPI 2022-07-26 /pmc/articles/PMC9330306/ /pubmed/35897943 http://dx.doi.org/10.3390/molecules27154767 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barbosa, Sandro L.
Nelson, David Lee
Freitas, Milton de S.
dos Santos, Wallans Torres Pio
Klein, Stanlei I.
Clososki, Giuliano C.
Caires, Franco J.
Wentz, Alexandre P.
Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
title Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
title_full Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
title_fullStr Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
title_full_unstemmed Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
title_short Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
title_sort tandem transesterification–esterification reactions using a hydrophilic sulfonated silica catalyst for the synthesis of wintergreen oil from acetylsalicylic acid promoted by microwave irradiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330306/
https://www.ncbi.nlm.nih.gov/pubmed/35897943
http://dx.doi.org/10.3390/molecules27154767
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