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CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling

BACKGROUND: The correlation between elevated T-cell infiltration and improved survival of ovarian cancer (OvCa) patients suggests that endogenous tumor-infiltrating lymphocytes (TIL) possess some degree of antitumor activity that can be harnessed for OvCa immunotherapy. We previously optimized a pro...

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Detalles Bibliográficos
Autores principales:	Fix, Samantha M, Forget, Marie-Andrée, Sakellariou-Thompson, Donastas, Wang, Yunfei, Griffiths, Tamara M, Lee, Minjung, Haymaker, Cara L, Dominguez, Ana Lucía, Basar, Rafet, Reyes, Christopher, Kumar, Sanjay, Meyer, Larissa A, Hwu, Patrick, Bernatchez, Chantale, Jazaeri, Amir A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330322/ https://www.ncbi.nlm.nih.gov/pubmed/35882447 http://dx.doi.org/10.1136/jitc-2021-003750

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