Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection

SARS-CoV-2 Omicron variant is spreading worldwide, causing unprecedented epidemic peaks due to its transmissibility and immune evasion. We searched in the archive of the Regional Microbiology Laboratory (Umbria, Italy) for immediate reinfection (i.e. infection occurring 25–60 days from primary infec...

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Autores principales: Mencacci, Antonella, Gili, Alessio, Camilloni, Barbara, Bicchieraro, Giulia, Spaccapelo, Roberta, Bietta, Carla, Stracci, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330370/
https://www.ncbi.nlm.nih.gov/pubmed/35963101
http://dx.doi.org/10.1016/j.jiph.2022.07.013
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author Mencacci, Antonella
Gili, Alessio
Camilloni, Barbara
Bicchieraro, Giulia
Spaccapelo, Roberta
Bietta, Carla
Stracci, Fabrizio
author_facet Mencacci, Antonella
Gili, Alessio
Camilloni, Barbara
Bicchieraro, Giulia
Spaccapelo, Roberta
Bietta, Carla
Stracci, Fabrizio
author_sort Mencacci, Antonella
collection PubMed
description SARS-CoV-2 Omicron variant is spreading worldwide, causing unprecedented epidemic peaks due to its transmissibility and immune evasion. We searched in the archive of the Regional Microbiology Laboratory (Umbria, Italy) for immediate reinfection (i.e. infection occurring 25–60 days from primary infection) among 454,764 RT-PCR tests from 261,217 individuals. Lineage heterogeneity was assessed by S gene target failure phenomenon or whole genome sequencing. We found that BA.1 Omicron variant may cause immediate reinfection of patients just recovered from Delta infection. Immediate reinfection was not observed for any other combination of variants, including Delta over Alpha variant and BA.2 over BA.1 Omicron lineage.
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spelling pubmed-93303702022-07-28 Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection Mencacci, Antonella Gili, Alessio Camilloni, Barbara Bicchieraro, Giulia Spaccapelo, Roberta Bietta, Carla Stracci, Fabrizio J Infect Public Health Article SARS-CoV-2 Omicron variant is spreading worldwide, causing unprecedented epidemic peaks due to its transmissibility and immune evasion. We searched in the archive of the Regional Microbiology Laboratory (Umbria, Italy) for immediate reinfection (i.e. infection occurring 25–60 days from primary infection) among 454,764 RT-PCR tests from 261,217 individuals. Lineage heterogeneity was assessed by S gene target failure phenomenon or whole genome sequencing. We found that BA.1 Omicron variant may cause immediate reinfection of patients just recovered from Delta infection. Immediate reinfection was not observed for any other combination of variants, including Delta over Alpha variant and BA.2 over BA.1 Omicron lineage. The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2022-09 2022-07-28 /pmc/articles/PMC9330370/ /pubmed/35963101 http://dx.doi.org/10.1016/j.jiph.2022.07.013 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mencacci, Antonella
Gili, Alessio
Camilloni, Barbara
Bicchieraro, Giulia
Spaccapelo, Roberta
Bietta, Carla
Stracci, Fabrizio
Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
title Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
title_full Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
title_fullStr Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
title_full_unstemmed Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
title_short Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
title_sort immediate reinfection with omicron variant after clearance of a previous sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330370/
https://www.ncbi.nlm.nih.gov/pubmed/35963101
http://dx.doi.org/10.1016/j.jiph.2022.07.013
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