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The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity

The lack of resistance of plastic objects to various pathogens and their increasing activity in our daily life have made researchers develop polymeric materials with biocidal properties. Hence, this paper describes the thermoplastic composites of Polyamide 12 mixed with 1–5 wt % of the nanoparticles...

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Autores principales: Latko-Durałek, Paulina, Misiak, Michał, Staniszewska, Monika, Rosłoniec, Karina, Grodzik, Marta, Socha, Robert P., Krzan, Marcel, Bażanów, Barbara, Pogorzelska, Aleksandra, Boczkowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330415/
https://www.ncbi.nlm.nih.gov/pubmed/35893987
http://dx.doi.org/10.3390/polym14153025
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author Latko-Durałek, Paulina
Misiak, Michał
Staniszewska, Monika
Rosłoniec, Karina
Grodzik, Marta
Socha, Robert P.
Krzan, Marcel
Bażanów, Barbara
Pogorzelska, Aleksandra
Boczkowska, Anna
author_facet Latko-Durałek, Paulina
Misiak, Michał
Staniszewska, Monika
Rosłoniec, Karina
Grodzik, Marta
Socha, Robert P.
Krzan, Marcel
Bażanów, Barbara
Pogorzelska, Aleksandra
Boczkowska, Anna
author_sort Latko-Durałek, Paulina
collection PubMed
description The lack of resistance of plastic objects to various pathogens and their increasing activity in our daily life have made researchers develop polymeric materials with biocidal properties. Hence, this paper describes the thermoplastic composites of Polyamide 12 mixed with 1–5 wt % of the nanoparticles of zinc, copper, and titanium oxides prepared by a twin-screw extrusion process and injection moulding. A satisfactory biocidal activity of polyamide 12 nanocomposites was obtained thanks to homogenously dispersed metal oxides in the polymer matrix and the wettability of the metal oxides by PA12. At 4 wt % of the metal oxides, the contact angles were the lowest and it resulted in obtaining the highest reduction rate of the Escherichia coli (87%), Candida albicans (53%), and Herpes simplex 1 (90%). The interactions of the nanocomposites with the fibroblasts show early apoptosis (11.85–27.79%), late apoptosis (0.81–5.04%), and necrosis (0.18–0.31%), which confirms the lack of toxicity of used metal oxides. Moreover, the used oxides affect slightly the thermal and rheological properties of PA12, which was determined by oscillatory rheology, thermogravimetric analysis, and differential scanning calorimetry.
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spelling pubmed-93304152022-07-29 The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity Latko-Durałek, Paulina Misiak, Michał Staniszewska, Monika Rosłoniec, Karina Grodzik, Marta Socha, Robert P. Krzan, Marcel Bażanów, Barbara Pogorzelska, Aleksandra Boczkowska, Anna Polymers (Basel) Article The lack of resistance of plastic objects to various pathogens and their increasing activity in our daily life have made researchers develop polymeric materials with biocidal properties. Hence, this paper describes the thermoplastic composites of Polyamide 12 mixed with 1–5 wt % of the nanoparticles of zinc, copper, and titanium oxides prepared by a twin-screw extrusion process and injection moulding. A satisfactory biocidal activity of polyamide 12 nanocomposites was obtained thanks to homogenously dispersed metal oxides in the polymer matrix and the wettability of the metal oxides by PA12. At 4 wt % of the metal oxides, the contact angles were the lowest and it resulted in obtaining the highest reduction rate of the Escherichia coli (87%), Candida albicans (53%), and Herpes simplex 1 (90%). The interactions of the nanocomposites with the fibroblasts show early apoptosis (11.85–27.79%), late apoptosis (0.81–5.04%), and necrosis (0.18–0.31%), which confirms the lack of toxicity of used metal oxides. Moreover, the used oxides affect slightly the thermal and rheological properties of PA12, which was determined by oscillatory rheology, thermogravimetric analysis, and differential scanning calorimetry. MDPI 2022-07-26 /pmc/articles/PMC9330415/ /pubmed/35893987 http://dx.doi.org/10.3390/polym14153025 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Latko-Durałek, Paulina
Misiak, Michał
Staniszewska, Monika
Rosłoniec, Karina
Grodzik, Marta
Socha, Robert P.
Krzan, Marcel
Bażanów, Barbara
Pogorzelska, Aleksandra
Boczkowska, Anna
The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity
title The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity
title_full The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity
title_fullStr The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity
title_full_unstemmed The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity
title_short The Composites of Polyamide 12 and Metal Oxides with High Antimicrobial Activity
title_sort composites of polyamide 12 and metal oxides with high antimicrobial activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330415/
https://www.ncbi.nlm.nih.gov/pubmed/35893987
http://dx.doi.org/10.3390/polym14153025
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