Cargando…
Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopaus...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330421/ https://www.ncbi.nlm.nih.gov/pubmed/35893240 http://dx.doi.org/10.3390/metabo12080673 |
_version_ | 1784758156719554560 |
---|---|
author | Krakowiak, Jan Raczkiewicz, Dorota Humeniuk, Ewa Wdowiak, Artur Wróbel, Andrzej Bojar, Iwona |
author_facet | Krakowiak, Jan Raczkiewicz, Dorota Humeniuk, Ewa Wdowiak, Artur Wróbel, Andrzej Bojar, Iwona |
author_sort | Krakowiak, Jan |
collection | PubMed |
description | The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopausal and 202 post-menopausal women. ERα polymorphism: Xba I and Pvu II, MetS, BMI, and serum estrogen concentration were analyzed. MetS was found in 29% of the peri-menopausal women and in 21% of the post-menopausal women. BMI did not significantly differ between the peri- and post-menopausal women (≈42% were normal weight, ≈40% were overweight, and ≈18% were obese), (p = 0.82). Serum estrogen concentration in the peri-menopausal women was 91 ± 75 pg/mL, while that in the post-menopausal women was 17 ± 9. pg/mL, on average. Peri-menopausal women with AA and TT genotypes of the ERα polymorphism have a lower risk of obesity and MetS and the co-existence of obesity and MetS, whereas those women with the G or C allele have a higher risk of those health problems. |
format | Online Article Text |
id | pubmed-9330421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93304212022-07-29 Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women Krakowiak, Jan Raczkiewicz, Dorota Humeniuk, Ewa Wdowiak, Artur Wróbel, Andrzej Bojar, Iwona Metabolites Article The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopausal and 202 post-menopausal women. ERα polymorphism: Xba I and Pvu II, MetS, BMI, and serum estrogen concentration were analyzed. MetS was found in 29% of the peri-menopausal women and in 21% of the post-menopausal women. BMI did not significantly differ between the peri- and post-menopausal women (≈42% were normal weight, ≈40% were overweight, and ≈18% were obese), (p = 0.82). Serum estrogen concentration in the peri-menopausal women was 91 ± 75 pg/mL, while that in the post-menopausal women was 17 ± 9. pg/mL, on average. Peri-menopausal women with AA and TT genotypes of the ERα polymorphism have a lower risk of obesity and MetS and the co-existence of obesity and MetS, whereas those women with the G or C allele have a higher risk of those health problems. MDPI 2022-07-22 /pmc/articles/PMC9330421/ /pubmed/35893240 http://dx.doi.org/10.3390/metabo12080673 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Krakowiak, Jan Raczkiewicz, Dorota Humeniuk, Ewa Wdowiak, Artur Wróbel, Andrzej Bojar, Iwona Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women |
title | Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women |
title_full | Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women |
title_fullStr | Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women |
title_full_unstemmed | Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women |
title_short | Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women |
title_sort | metabolic syndrome, bmi, and polymorphism of estrogen receptor-α in peri- and post-menopausal polish women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330421/ https://www.ncbi.nlm.nih.gov/pubmed/35893240 http://dx.doi.org/10.3390/metabo12080673 |
work_keys_str_mv | AT krakowiakjan metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen AT raczkiewiczdorota metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen AT humeniukewa metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen AT wdowiakartur metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen AT wrobelandrzej metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen AT bojariwona metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen |