Cargando…

Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women

The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopaus...

Descripción completa

Detalles Bibliográficos
Autores principales: Krakowiak, Jan, Raczkiewicz, Dorota, Humeniuk, Ewa, Wdowiak, Artur, Wróbel, Andrzej, Bojar, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330421/
https://www.ncbi.nlm.nih.gov/pubmed/35893240
http://dx.doi.org/10.3390/metabo12080673
_version_ 1784758156719554560
author Krakowiak, Jan
Raczkiewicz, Dorota
Humeniuk, Ewa
Wdowiak, Artur
Wróbel, Andrzej
Bojar, Iwona
author_facet Krakowiak, Jan
Raczkiewicz, Dorota
Humeniuk, Ewa
Wdowiak, Artur
Wróbel, Andrzej
Bojar, Iwona
author_sort Krakowiak, Jan
collection PubMed
description The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopausal and 202 post-menopausal women. ERα polymorphism: Xba I and Pvu II, MetS, BMI, and serum estrogen concentration were analyzed. MetS was found in 29% of the peri-menopausal women and in 21% of the post-menopausal women. BMI did not significantly differ between the peri- and post-menopausal women (≈42% were normal weight, ≈40% were overweight, and ≈18% were obese), (p = 0.82). Serum estrogen concentration in the peri-menopausal women was 91 ± 75 pg/mL, while that in the post-menopausal women was 17 ± 9. pg/mL, on average. Peri-menopausal women with AA and TT genotypes of the ERα polymorphism have a lower risk of obesity and MetS and the co-existence of obesity and MetS, whereas those women with the G or C allele have a higher risk of those health problems.
format Online
Article
Text
id pubmed-9330421
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93304212022-07-29 Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women Krakowiak, Jan Raczkiewicz, Dorota Humeniuk, Ewa Wdowiak, Artur Wróbel, Andrzej Bojar, Iwona Metabolites Article The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopausal and 202 post-menopausal women. ERα polymorphism: Xba I and Pvu II, MetS, BMI, and serum estrogen concentration were analyzed. MetS was found in 29% of the peri-menopausal women and in 21% of the post-menopausal women. BMI did not significantly differ between the peri- and post-menopausal women (≈42% were normal weight, ≈40% were overweight, and ≈18% were obese), (p = 0.82). Serum estrogen concentration in the peri-menopausal women was 91 ± 75 pg/mL, while that in the post-menopausal women was 17 ± 9. pg/mL, on average. Peri-menopausal women with AA and TT genotypes of the ERα polymorphism have a lower risk of obesity and MetS and the co-existence of obesity and MetS, whereas those women with the G or C allele have a higher risk of those health problems. MDPI 2022-07-22 /pmc/articles/PMC9330421/ /pubmed/35893240 http://dx.doi.org/10.3390/metabo12080673 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krakowiak, Jan
Raczkiewicz, Dorota
Humeniuk, Ewa
Wdowiak, Artur
Wróbel, Andrzej
Bojar, Iwona
Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
title Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
title_full Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
title_fullStr Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
title_full_unstemmed Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
title_short Metabolic Syndrome, BMI, and Polymorphism of Estrogen Receptor-α in Peri- and Post-Menopausal Polish Women
title_sort metabolic syndrome, bmi, and polymorphism of estrogen receptor-α in peri- and post-menopausal polish women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330421/
https://www.ncbi.nlm.nih.gov/pubmed/35893240
http://dx.doi.org/10.3390/metabo12080673
work_keys_str_mv AT krakowiakjan metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen
AT raczkiewiczdorota metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen
AT humeniukewa metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen
AT wdowiakartur metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen
AT wrobelandrzej metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen
AT bojariwona metabolicsyndromebmiandpolymorphismofestrogenreceptorainperiandpostmenopausalpolishwomen