Role and mechanism of miR-211 in human cancer

MircoRNA (miRNA), which are a group of small, and highly conserved non-coding RNA consisting of 18-25 nucleotides, can modulate gene expression at post-transcriptional level, through complementary binding to the 3ʹ-untranslated region (3ʹ-UTR) of numerous target genes. Emerging evidence indicates th...

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Detalles Bibliográficos
Autores principales: Ye, Lingling, Wang, Fen, Wang, Jinyan, Wu, Hao, Yang, Hui, Yang, Zhaohui, Huang, Haiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330454/
https://www.ncbi.nlm.nih.gov/pubmed/35912006
http://dx.doi.org/10.7150/jca.71401
Descripción
Sumario:MircoRNA (miRNA), which are a group of small, and highly conserved non-coding RNA consisting of 18-25 nucleotides, can modulate gene expression at post-transcriptional level, through complementary binding to the 3ʹ-untranslated region (3ʹ-UTR) of numerous target genes. Emerging evidence indicates that miRNAs play critical roles in tumorigenesis and progression of cancer. Among them, miR-211 has been extensively studied in multiple cancers. The expression of miR-211 significantly varies with cancer types and may be used as a potential prognostic marker for cancer. MiR-211 can regulate multiple biological processes in cancer, including proliferation, apoptosis, metastasis and drug resistance. Additionally, several factors may contribute to the dysregulation of miR-211 in cancer. Consequently, this review aims to discuss the novel findings that highlight latent value of miR-211 in the prognosis assessment and treatment of cancer.

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