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Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality

Statin use and its impact on long-term clinical outcomes in active cancer patients following acute myocardial infarction (MI) remains insufficiently elucidated. Of the 1011 consecutive acute MI patients treated invasively between 2012 and 2017, cancer was identified in 134 (13.3%) subjects. All pati...

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Autores principales: Stepien, Konrad, Nowak, Karol, Kachnic, Natalia, Horosin, Grzegorz, Walczak, Piotr, Karcinska, Aleksandra, Schwarz, Tomasz, Wojtas, Mariusz, Zalewska, Magdalena, Pastuszak, Maksymilian, Wegrzyn, Bogdan, Nessler, Jadwiga, Zalewski, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330549/
https://www.ncbi.nlm.nih.gov/pubmed/35893743
http://dx.doi.org/10.3390/ph15080919
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author Stepien, Konrad
Nowak, Karol
Kachnic, Natalia
Horosin, Grzegorz
Walczak, Piotr
Karcinska, Aleksandra
Schwarz, Tomasz
Wojtas, Mariusz
Zalewska, Magdalena
Pastuszak, Maksymilian
Wegrzyn, Bogdan
Nessler, Jadwiga
Zalewski, Jarosław
author_facet Stepien, Konrad
Nowak, Karol
Kachnic, Natalia
Horosin, Grzegorz
Walczak, Piotr
Karcinska, Aleksandra
Schwarz, Tomasz
Wojtas, Mariusz
Zalewska, Magdalena
Pastuszak, Maksymilian
Wegrzyn, Bogdan
Nessler, Jadwiga
Zalewski, Jarosław
author_sort Stepien, Konrad
collection PubMed
description Statin use and its impact on long-term clinical outcomes in active cancer patients following acute myocardial infarction (MI) remains insufficiently elucidated. Of the 1011 consecutive acute MI patients treated invasively between 2012 and 2017, cancer was identified in 134 (13.3%) subjects. All patients were observed within a median follow-up of 69.2 (37.8–79.9) months. On discharge, statins were prescribed less frequently in MI patients with cancer as compared to the non-cancer MI population (79.9% vs. 91.4%, p < 0.001). The most common statin in both groups was atorvastatin. The long-term mortality was higher in MI patients not treated vs. those treated with statins, both in non-cancer (29.5%/year vs. 6.7%/year, p < 0.001) and cancer groups (53.9%/year vs. 24.9%/year, p < 0.05), respectively. Patient’s age (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.03–1.05, p < 0.001, per year), an active cancer (HR 2.42, 95% CI 1.89–3.11, p < 0.001), hemoglobin level (HR 1.14, 95% CI 1.09–1.20, p < 0.001, per 1 g/dL decrease), and no statin on discharge (HR 2.13, 95% CI 1.61–2.78, p < 0.001) independently increased long-term mortality. In MI patients, simultaneous diagnosis of an active cancer was associated with less frequently prescribed statins on discharge. Irrespective of cancer diagnosis, no statin use was found as an independent predictor of increased long-term mortality.
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spelling pubmed-93305492022-07-29 Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality Stepien, Konrad Nowak, Karol Kachnic, Natalia Horosin, Grzegorz Walczak, Piotr Karcinska, Aleksandra Schwarz, Tomasz Wojtas, Mariusz Zalewska, Magdalena Pastuszak, Maksymilian Wegrzyn, Bogdan Nessler, Jadwiga Zalewski, Jarosław Pharmaceuticals (Basel) Article Statin use and its impact on long-term clinical outcomes in active cancer patients following acute myocardial infarction (MI) remains insufficiently elucidated. Of the 1011 consecutive acute MI patients treated invasively between 2012 and 2017, cancer was identified in 134 (13.3%) subjects. All patients were observed within a median follow-up of 69.2 (37.8–79.9) months. On discharge, statins were prescribed less frequently in MI patients with cancer as compared to the non-cancer MI population (79.9% vs. 91.4%, p < 0.001). The most common statin in both groups was atorvastatin. The long-term mortality was higher in MI patients not treated vs. those treated with statins, both in non-cancer (29.5%/year vs. 6.7%/year, p < 0.001) and cancer groups (53.9%/year vs. 24.9%/year, p < 0.05), respectively. Patient’s age (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.03–1.05, p < 0.001, per year), an active cancer (HR 2.42, 95% CI 1.89–3.11, p < 0.001), hemoglobin level (HR 1.14, 95% CI 1.09–1.20, p < 0.001, per 1 g/dL decrease), and no statin on discharge (HR 2.13, 95% CI 1.61–2.78, p < 0.001) independently increased long-term mortality. In MI patients, simultaneous diagnosis of an active cancer was associated with less frequently prescribed statins on discharge. Irrespective of cancer diagnosis, no statin use was found as an independent predictor of increased long-term mortality. MDPI 2022-07-25 /pmc/articles/PMC9330549/ /pubmed/35893743 http://dx.doi.org/10.3390/ph15080919 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stepien, Konrad
Nowak, Karol
Kachnic, Natalia
Horosin, Grzegorz
Walczak, Piotr
Karcinska, Aleksandra
Schwarz, Tomasz
Wojtas, Mariusz
Zalewska, Magdalena
Pastuszak, Maksymilian
Wegrzyn, Bogdan
Nessler, Jadwiga
Zalewski, Jarosław
Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
title Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
title_full Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
title_fullStr Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
title_full_unstemmed Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
title_short Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
title_sort statin use in cancer patients with acute myocardial infarction and its impact on long-term mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330549/
https://www.ncbi.nlm.nih.gov/pubmed/35893743
http://dx.doi.org/10.3390/ph15080919
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