Cargando…
Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survi...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330568/ https://www.ncbi.nlm.nih.gov/pubmed/35897440 http://dx.doi.org/10.3390/ijerph19159059 |
_version_ | 1784758193235165184 |
---|---|
author | Abdol Manap, Nurliza Ng, Beng Kwang Phon, Su Ee Abdul Karim, Abdul Kadir Lim, Pei Shan Fadhil, Maimunah |
author_facet | Abdol Manap, Nurliza Ng, Beng Kwang Phon, Su Ee Abdul Karim, Abdul Kadir Lim, Pei Shan Fadhil, Maimunah |
author_sort | Abdol Manap, Nurliza |
collection | PubMed |
description | Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects’ histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group. |
format | Online Article Text |
id | pubmed-9330568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93305682022-07-29 Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome Abdol Manap, Nurliza Ng, Beng Kwang Phon, Su Ee Abdul Karim, Abdul Kadir Lim, Pei Shan Fadhil, Maimunah Int J Environ Res Public Health Article Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects’ histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group. MDPI 2022-07-25 /pmc/articles/PMC9330568/ /pubmed/35897440 http://dx.doi.org/10.3390/ijerph19159059 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abdol Manap, Nurliza Ng, Beng Kwang Phon, Su Ee Abdul Karim, Abdul Kadir Lim, Pei Shan Fadhil, Maimunah Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome |
title | Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome |
title_full | Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome |
title_fullStr | Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome |
title_full_unstemmed | Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome |
title_short | Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome |
title_sort | endometrial cancer in pre-menopausal women and younger: risk factors and outcome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330568/ https://www.ncbi.nlm.nih.gov/pubmed/35897440 http://dx.doi.org/10.3390/ijerph19159059 |
work_keys_str_mv | AT abdolmanapnurliza endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome AT ngbengkwang endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome AT phonsuee endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome AT abdulkarimabdulkadir endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome AT limpeishan endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome AT fadhilmaimunah endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome |