Cargando…

Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome

Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survi...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdol Manap, Nurliza, Ng, Beng Kwang, Phon, Su Ee, Abdul Karim, Abdul Kadir, Lim, Pei Shan, Fadhil, Maimunah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330568/
https://www.ncbi.nlm.nih.gov/pubmed/35897440
http://dx.doi.org/10.3390/ijerph19159059
_version_ 1784758193235165184
author Abdol Manap, Nurliza
Ng, Beng Kwang
Phon, Su Ee
Abdul Karim, Abdul Kadir
Lim, Pei Shan
Fadhil, Maimunah
author_facet Abdol Manap, Nurliza
Ng, Beng Kwang
Phon, Su Ee
Abdul Karim, Abdul Kadir
Lim, Pei Shan
Fadhil, Maimunah
author_sort Abdol Manap, Nurliza
collection PubMed
description Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects’ histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group.
format Online
Article
Text
id pubmed-9330568
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93305682022-07-29 Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome Abdol Manap, Nurliza Ng, Beng Kwang Phon, Su Ee Abdul Karim, Abdul Kadir Lim, Pei Shan Fadhil, Maimunah Int J Environ Res Public Health Article Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects’ histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group. MDPI 2022-07-25 /pmc/articles/PMC9330568/ /pubmed/35897440 http://dx.doi.org/10.3390/ijerph19159059 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdol Manap, Nurliza
Ng, Beng Kwang
Phon, Su Ee
Abdul Karim, Abdul Kadir
Lim, Pei Shan
Fadhil, Maimunah
Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
title Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
title_full Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
title_fullStr Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
title_full_unstemmed Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
title_short Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
title_sort endometrial cancer in pre-menopausal women and younger: risk factors and outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330568/
https://www.ncbi.nlm.nih.gov/pubmed/35897440
http://dx.doi.org/10.3390/ijerph19159059
work_keys_str_mv AT abdolmanapnurliza endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome
AT ngbengkwang endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome
AT phonsuee endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome
AT abdulkarimabdulkadir endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome
AT limpeishan endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome
AT fadhilmaimunah endometrialcancerinpremenopausalwomenandyoungerriskfactorsandoutcome