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Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)

Almost two and a half years after the appearance of the first cases of SARS-CoV-2 in December 2019, more than 500 million people have been infected with SARS-CoV-2 and over 6 million have died of it worldwide. In terms of the pediatric cohort, it already became evident at an early stage that the inf...

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Autores principales: Meyer, Meike, Ruebsteck, Esra, Dewald, Felix, Klein, Florian, Lehmann, Clara, Huenseler, Christoph, Weber, Lutz Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330606/
https://www.ncbi.nlm.nih.gov/pubmed/35893673
http://dx.doi.org/10.3390/v14081607
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author Meyer, Meike
Ruebsteck, Esra
Dewald, Felix
Klein, Florian
Lehmann, Clara
Huenseler, Christoph
Weber, Lutz Thorsten
author_facet Meyer, Meike
Ruebsteck, Esra
Dewald, Felix
Klein, Florian
Lehmann, Clara
Huenseler, Christoph
Weber, Lutz Thorsten
author_sort Meyer, Meike
collection PubMed
description Almost two and a half years after the appearance of the first cases of SARS-CoV-2 in December 2019, more than 500 million people have been infected with SARS-CoV-2 and over 6 million have died of it worldwide. In terms of the pediatric cohort, it already became evident at an early stage that the infection causes milder symptoms in children and rarely runs a fatal course. Objective: This work presents data gathered over a period of over two years in patients between the age of 0 and 18 years. The aim is to provide information on the clinical aspects of the five different SARS-CoV-2 waves. Methods: Between 13 March 2020 and 22 April 2022, all nucleic acid amplification tests (NAATs) of children who received a swab for SARS-CoV-2 at our clinic were included. Data were collected on standardized questionnaires. The analysis of the data was anonymized and retrospective. Results: We investigated 21,635 NAATs, of which 1028 of the tests were positive (4.8%). The highest rate of positive results was observed in the fifth wave (541/2.292 NAATs (23.6%)). Most of the children who were hospitalized were hospitalized in wave three (22.9%). The availability of a vaccine was followed by a decrease in positive NAATs in the corresponding age group thereafter. Conclusions: These data underline the fact that children infected with SARS-CoV-2, regardless of which VOC, are often only mildly affected. Vaccinations seem to remain the key to avoid massive numbers of infected people and a potential collapse of the healthcare systems.
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spelling pubmed-93306062022-07-29 Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635) Meyer, Meike Ruebsteck, Esra Dewald, Felix Klein, Florian Lehmann, Clara Huenseler, Christoph Weber, Lutz Thorsten Viruses Article Almost two and a half years after the appearance of the first cases of SARS-CoV-2 in December 2019, more than 500 million people have been infected with SARS-CoV-2 and over 6 million have died of it worldwide. In terms of the pediatric cohort, it already became evident at an early stage that the infection causes milder symptoms in children and rarely runs a fatal course. Objective: This work presents data gathered over a period of over two years in patients between the age of 0 and 18 years. The aim is to provide information on the clinical aspects of the five different SARS-CoV-2 waves. Methods: Between 13 March 2020 and 22 April 2022, all nucleic acid amplification tests (NAATs) of children who received a swab for SARS-CoV-2 at our clinic were included. Data were collected on standardized questionnaires. The analysis of the data was anonymized and retrospective. Results: We investigated 21,635 NAATs, of which 1028 of the tests were positive (4.8%). The highest rate of positive results was observed in the fifth wave (541/2.292 NAATs (23.6%)). Most of the children who were hospitalized were hospitalized in wave three (22.9%). The availability of a vaccine was followed by a decrease in positive NAATs in the corresponding age group thereafter. Conclusions: These data underline the fact that children infected with SARS-CoV-2, regardless of which VOC, are often only mildly affected. Vaccinations seem to remain the key to avoid massive numbers of infected people and a potential collapse of the healthcare systems. MDPI 2022-07-23 /pmc/articles/PMC9330606/ /pubmed/35893673 http://dx.doi.org/10.3390/v14081607 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meyer, Meike
Ruebsteck, Esra
Dewald, Felix
Klein, Florian
Lehmann, Clara
Huenseler, Christoph
Weber, Lutz Thorsten
Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)
title Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)
title_full Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)
title_fullStr Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)
title_full_unstemmed Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)
title_short Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022—Data from a Local Cohort in Cologne, Germany (n = 21,635)
title_sort clinical aspects of the subsequent sars-cov-2 waves in children from 2020 to 2022—data from a local cohort in cologne, germany (n = 21,635)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330606/
https://www.ncbi.nlm.nih.gov/pubmed/35893673
http://dx.doi.org/10.3390/v14081607
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