Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review

Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be l...

Descripción completa

Detalles Bibliográficos
Autores principales: Nitro, Letizia, Bulfamante, Antonio Mario, Rosso, Cecilia, Saibene, Alberto Maria, Arnone, Flavio, Felisati, Giovanni, Pipolo, Carlotta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330752/
https://www.ncbi.nlm.nih.gov/pubmed/35880360
http://dx.doi.org/10.14639/0392-100X-N1911
Descripción
Sumario:Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP.

Ejemplares similares