Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review

Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be l...

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Autores principales: Nitro, Letizia, Bulfamante, Antonio Mario, Rosso, Cecilia, Saibene, Alberto Maria, Arnone, Flavio, Felisati, Giovanni, Pipolo, Carlotta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330752/
https://www.ncbi.nlm.nih.gov/pubmed/35880360
http://dx.doi.org/10.14639/0392-100X-N1911
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author Nitro, Letizia
Bulfamante, Antonio Mario
Rosso, Cecilia
Saibene, Alberto Maria
Arnone, Flavio
Felisati, Giovanni
Pipolo, Carlotta
author_facet Nitro, Letizia
Bulfamante, Antonio Mario
Rosso, Cecilia
Saibene, Alberto Maria
Arnone, Flavio
Felisati, Giovanni
Pipolo, Carlotta
author_sort Nitro, Letizia
collection PubMed
description Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP.
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spelling pubmed-93307522022-08-09 Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review Nitro, Letizia Bulfamante, Antonio Mario Rosso, Cecilia Saibene, Alberto Maria Arnone, Flavio Felisati, Giovanni Pipolo, Carlotta Acta Otorhinolaryngol Ital Review Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP. Pacini Editore Srl 2022-06-30 2022-06 /pmc/articles/PMC9330752/ /pubmed/35880360 http://dx.doi.org/10.14639/0392-100X-N1911 Text en Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Review
Nitro, Letizia
Bulfamante, Antonio Mario
Rosso, Cecilia
Saibene, Alberto Maria
Arnone, Flavio
Felisati, Giovanni
Pipolo, Carlotta
Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
title Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
title_full Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
title_fullStr Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
title_full_unstemmed Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
title_short Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
title_sort adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. case report and narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330752/
https://www.ncbi.nlm.nih.gov/pubmed/35880360
http://dx.doi.org/10.14639/0392-100X-N1911
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