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Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330892/ https://www.ncbi.nlm.nih.gov/pubmed/35892934 http://dx.doi.org/10.3390/md20080466 |
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author | Ahmed, Salman Alam, Waqas Jeandet, Philippe Aschner, Michael Alsharif, Khalaf F. Saso, Luciano Khan, Haroon |
author_facet | Ahmed, Salman Alam, Waqas Jeandet, Philippe Aschner, Michael Alsharif, Khalaf F. Saso, Luciano Khan, Haroon |
author_sort | Ahmed, Salman |
collection | PubMed |
description | Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa. |
format | Online Article Text |
id | pubmed-9330892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93308922022-07-29 Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights Ahmed, Salman Alam, Waqas Jeandet, Philippe Aschner, Michael Alsharif, Khalaf F. Saso, Luciano Khan, Haroon Mar Drugs Review Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa. MDPI 2022-07-22 /pmc/articles/PMC9330892/ /pubmed/35892934 http://dx.doi.org/10.3390/md20080466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ahmed, Salman Alam, Waqas Jeandet, Philippe Aschner, Michael Alsharif, Khalaf F. Saso, Luciano Khan, Haroon Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights |
title | Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights |
title_full | Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights |
title_fullStr | Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights |
title_full_unstemmed | Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights |
title_short | Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights |
title_sort | therapeutic potential of marine peptides in prostate cancer: mechanistic insights |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330892/ https://www.ncbi.nlm.nih.gov/pubmed/35892934 http://dx.doi.org/10.3390/md20080466 |
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