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Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain...

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Autores principales: Ahmed, Salman, Alam, Waqas, Jeandet, Philippe, Aschner, Michael, Alsharif, Khalaf F., Saso, Luciano, Khan, Haroon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330892/
https://www.ncbi.nlm.nih.gov/pubmed/35892934
http://dx.doi.org/10.3390/md20080466
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author Ahmed, Salman
Alam, Waqas
Jeandet, Philippe
Aschner, Michael
Alsharif, Khalaf F.
Saso, Luciano
Khan, Haroon
author_facet Ahmed, Salman
Alam, Waqas
Jeandet, Philippe
Aschner, Michael
Alsharif, Khalaf F.
Saso, Luciano
Khan, Haroon
author_sort Ahmed, Salman
collection PubMed
description Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.
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spelling pubmed-93308922022-07-29 Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights Ahmed, Salman Alam, Waqas Jeandet, Philippe Aschner, Michael Alsharif, Khalaf F. Saso, Luciano Khan, Haroon Mar Drugs Review Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa. MDPI 2022-07-22 /pmc/articles/PMC9330892/ /pubmed/35892934 http://dx.doi.org/10.3390/md20080466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ahmed, Salman
Alam, Waqas
Jeandet, Philippe
Aschner, Michael
Alsharif, Khalaf F.
Saso, Luciano
Khan, Haroon
Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
title Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
title_full Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
title_fullStr Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
title_full_unstemmed Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
title_short Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
title_sort therapeutic potential of marine peptides in prostate cancer: mechanistic insights
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330892/
https://www.ncbi.nlm.nih.gov/pubmed/35892934
http://dx.doi.org/10.3390/md20080466
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