Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38/Elk-1 pathway

BACKGROUND: Asprosin, a newly discovered adipokine, is a C-terminal cleavage product of profibrillin. Asprosin has been reported to participate in lipid metabolism and cardiovascular disease, but its role in atherogenesis remains elusive. METHODS: Asprosin was overexpressed in THP-1 macrophage-deriv...

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Detalles Bibliográficos
Autores principales: Zou, Jin, Xu, Can, Zhao, Zhen-Wang, Yin, Shan-Hui, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331044/
https://www.ncbi.nlm.nih.gov/pubmed/35902881
http://dx.doi.org/10.1186/s12967-022-03542-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331044/
https://www.ncbi.nlm.nih.gov/pubmed/35902881
http://dx.doi.org/10.1186/s12967-022-03542-0

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