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The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is foc...

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Autores principales: Heris, Reza Mosaddeghi, Shirvaliloo, Milad, Abbaspour-Aghdam, Sanaz, Hazrati, Ali, Shariati, Ali, Youshanlouei, Hamed Rahmani, Niaragh, Farhad Jadidi, Valizadeh, Hamed, Ahmadi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331055/
https://www.ncbi.nlm.nih.gov/pubmed/35902981
http://dx.doi.org/10.1186/s13287-022-03050-4
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author Heris, Reza Mosaddeghi
Shirvaliloo, Milad
Abbaspour-Aghdam, Sanaz
Hazrati, Ali
Shariati, Ali
Youshanlouei, Hamed Rahmani
Niaragh, Farhad Jadidi
Valizadeh, Hamed
Ahmadi, Majid
author_facet Heris, Reza Mosaddeghi
Shirvaliloo, Milad
Abbaspour-Aghdam, Sanaz
Hazrati, Ali
Shariati, Ali
Youshanlouei, Hamed Rahmani
Niaragh, Farhad Jadidi
Valizadeh, Hamed
Ahmadi, Majid
author_sort Heris, Reza Mosaddeghi
collection PubMed
description Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more pathology-oriented therapeutic approach. Regenerative cell therapy has provided us with an unrivalled platform for evaluating potentially effective novel methods for treating neurodegenerative illnesses over the last two decades. Mesenchymal stem cells (MSCs) are most promising, as they can differentiate into dopaminergic neurons and produce neurotrophic substances. The precise process by which stem cells repair neuronal injury is unknown, and MSC-derived exosomes are suggested to be responsible for a significant portion of such effects. The present review discusses the application of mesenchymal stem cells and MSC-derived exosomes in PD treatment.
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spelling pubmed-93310552022-07-29 The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment Heris, Reza Mosaddeghi Shirvaliloo, Milad Abbaspour-Aghdam, Sanaz Hazrati, Ali Shariati, Ali Youshanlouei, Hamed Rahmani Niaragh, Farhad Jadidi Valizadeh, Hamed Ahmadi, Majid Stem Cell Res Ther Review Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more pathology-oriented therapeutic approach. Regenerative cell therapy has provided us with an unrivalled platform for evaluating potentially effective novel methods for treating neurodegenerative illnesses over the last two decades. Mesenchymal stem cells (MSCs) are most promising, as they can differentiate into dopaminergic neurons and produce neurotrophic substances. The precise process by which stem cells repair neuronal injury is unknown, and MSC-derived exosomes are suggested to be responsible for a significant portion of such effects. The present review discusses the application of mesenchymal stem cells and MSC-derived exosomes in PD treatment. BioMed Central 2022-07-28 /pmc/articles/PMC9331055/ /pubmed/35902981 http://dx.doi.org/10.1186/s13287-022-03050-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Heris, Reza Mosaddeghi
Shirvaliloo, Milad
Abbaspour-Aghdam, Sanaz
Hazrati, Ali
Shariati, Ali
Youshanlouei, Hamed Rahmani
Niaragh, Farhad Jadidi
Valizadeh, Hamed
Ahmadi, Majid
The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
title The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
title_full The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
title_fullStr The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
title_full_unstemmed The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
title_short The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
title_sort potential use of mesenchymal stem cells and their exosomes in parkinson’s disease treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331055/
https://www.ncbi.nlm.nih.gov/pubmed/35902981
http://dx.doi.org/10.1186/s13287-022-03050-4
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