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Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers

Vitamin D deficiency is prevalent in many developed countries, and several studies suggest that vitamin D plays an essential role in brain function. A recent study showed that vitamin D deficiency was closely associated with daytime sleepiness and shorter sleep time. The relationshipbetween vitamin...

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Autores principales: Jeon, Yi-Seon, Yu, Seungyeong, Kim, Chaeyeon, Lee, Hyuk Joo, Yoon, In-Young, Kim, Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331058/
https://www.ncbi.nlm.nih.gov/pubmed/35893875
http://dx.doi.org/10.3390/nu14153021
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author Jeon, Yi-Seon
Yu, Seungyeong
Kim, Chaeyeon
Lee, Hyuk Joo
Yoon, In-Young
Kim, Tae
author_facet Jeon, Yi-Seon
Yu, Seungyeong
Kim, Chaeyeon
Lee, Hyuk Joo
Yoon, In-Young
Kim, Tae
author_sort Jeon, Yi-Seon
collection PubMed
description Vitamin D deficiency is prevalent in many developed countries, and several studies suggest that vitamin D plays an essential role in brain function. A recent study showed that vitamin D deficiency was closely associated with daytime sleepiness and shorter sleep time. The relationshipbetween vitamin D levels and calcium levels is well established, and calcium level regulates slow-wave sleep generation. It is conceivable that the sleep disturbance in vitamin D deficiency may be due to an altered calcium level. Nonetheless, calcium levels, sleep disturbances, and activity rhythms have not been investigated directly. Therefore, we hypothesized that calcium and vitamin D levels might be important in regulating sleep and activity rhythm, and we analyzed the correlation with calcium levels by actigraphy analysis. Interestingly, a negative correlation was found between calcium level and sleep latency, total sleep time, use of sleep medicine, and daytime dysfunction among shift workers. In contrast, non-shift workers showed a negative correlation between the calcium level and the circadian phase. These findings suggest that low serum calcium levels may disrupt sleep–wake control and rest–activity rhythm, even if they are within the normal range.
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spelling pubmed-93310582022-07-29 Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers Jeon, Yi-Seon Yu, Seungyeong Kim, Chaeyeon Lee, Hyuk Joo Yoon, In-Young Kim, Tae Nutrients Article Vitamin D deficiency is prevalent in many developed countries, and several studies suggest that vitamin D plays an essential role in brain function. A recent study showed that vitamin D deficiency was closely associated with daytime sleepiness and shorter sleep time. The relationshipbetween vitamin D levels and calcium levels is well established, and calcium level regulates slow-wave sleep generation. It is conceivable that the sleep disturbance in vitamin D deficiency may be due to an altered calcium level. Nonetheless, calcium levels, sleep disturbances, and activity rhythms have not been investigated directly. Therefore, we hypothesized that calcium and vitamin D levels might be important in regulating sleep and activity rhythm, and we analyzed the correlation with calcium levels by actigraphy analysis. Interestingly, a negative correlation was found between calcium level and sleep latency, total sleep time, use of sleep medicine, and daytime dysfunction among shift workers. In contrast, non-shift workers showed a negative correlation between the calcium level and the circadian phase. These findings suggest that low serum calcium levels may disrupt sleep–wake control and rest–activity rhythm, even if they are within the normal range. MDPI 2022-07-22 /pmc/articles/PMC9331058/ /pubmed/35893875 http://dx.doi.org/10.3390/nu14153021 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeon, Yi-Seon
Yu, Seungyeong
Kim, Chaeyeon
Lee, Hyuk Joo
Yoon, In-Young
Kim, Tae
Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
title Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
title_full Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
title_fullStr Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
title_full_unstemmed Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
title_short Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
title_sort lower serum calcium levels associated with disrupted sleep and rest–activity rhythm in shift workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331058/
https://www.ncbi.nlm.nih.gov/pubmed/35893875
http://dx.doi.org/10.3390/nu14153021
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