Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors

Sulfated polysaccharides (SPS) from seaweeds have great biochemical and biotechnological potential. This study aimed to investigate the effect of SPS isolated from the seaweed Caulerpa sertularioides on adipogenic differentiation as a possible alternative treatment for obesity. The SPS-rich extract...

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Autores principales: Chaves Filho, Gildacio Pereira, Batista, Lucas Alighieri Neves Costa, de Medeiros, Silvia Regina Batistuzzo, Rocha, Hugo Alexandre Oliveira, Moreira, Susana Margarida Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331110/
https://www.ncbi.nlm.nih.gov/pubmed/35892938
http://dx.doi.org/10.3390/md20080470
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author Chaves Filho, Gildacio Pereira
Batista, Lucas Alighieri Neves Costa
de Medeiros, Silvia Regina Batistuzzo
Rocha, Hugo Alexandre Oliveira
Moreira, Susana Margarida Gomes
author_facet Chaves Filho, Gildacio Pereira
Batista, Lucas Alighieri Neves Costa
de Medeiros, Silvia Regina Batistuzzo
Rocha, Hugo Alexandre Oliveira
Moreira, Susana Margarida Gomes
author_sort Chaves Filho, Gildacio Pereira
collection PubMed
description Sulfated polysaccharides (SPS) from seaweeds have great biochemical and biotechnological potential. This study aimed to investigate the effect of SPS isolated from the seaweed Caulerpa sertularioides on adipogenic differentiation as a possible alternative treatment for obesity. The SPS-rich extract from the seaweed C. sertularioides was fractioned into three SPS-rich fractions (F0.5; F0.9; and F1.8) chemically characterized. Among these four samples, only F0.9 showed a significant inhibitory effect on adipogenesis of 3T3-L1 preadipocytes. Ten SPS-rich fractions were isolated from F0.9 through ion-exchange chromatography. However, only the fraction (CS0.2) containing a sulfated glucan was able to inhibit adipogenesis. CS0.2 reduces lipid accumulation and inhibits the expression of key adipogenic (PPARγ, C/EBPβ, and C/EBPα) and lipogenic markers (SREBP-1c, Fabp4, and CD36). The data points to the potential of sulfated glucan from C. sertularioides for the development of functional approaches in obesity management.
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spelling pubmed-93311102022-07-29 Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors Chaves Filho, Gildacio Pereira Batista, Lucas Alighieri Neves Costa de Medeiros, Silvia Regina Batistuzzo Rocha, Hugo Alexandre Oliveira Moreira, Susana Margarida Gomes Mar Drugs Article Sulfated polysaccharides (SPS) from seaweeds have great biochemical and biotechnological potential. This study aimed to investigate the effect of SPS isolated from the seaweed Caulerpa sertularioides on adipogenic differentiation as a possible alternative treatment for obesity. The SPS-rich extract from the seaweed C. sertularioides was fractioned into three SPS-rich fractions (F0.5; F0.9; and F1.8) chemically characterized. Among these four samples, only F0.9 showed a significant inhibitory effect on adipogenesis of 3T3-L1 preadipocytes. Ten SPS-rich fractions were isolated from F0.9 through ion-exchange chromatography. However, only the fraction (CS0.2) containing a sulfated glucan was able to inhibit adipogenesis. CS0.2 reduces lipid accumulation and inhibits the expression of key adipogenic (PPARγ, C/EBPβ, and C/EBPα) and lipogenic markers (SREBP-1c, Fabp4, and CD36). The data points to the potential of sulfated glucan from C. sertularioides for the development of functional approaches in obesity management. MDPI 2022-07-23 /pmc/articles/PMC9331110/ /pubmed/35892938 http://dx.doi.org/10.3390/md20080470 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chaves Filho, Gildacio Pereira
Batista, Lucas Alighieri Neves Costa
de Medeiros, Silvia Regina Batistuzzo
Rocha, Hugo Alexandre Oliveira
Moreira, Susana Margarida Gomes
Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
title Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
title_full Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
title_fullStr Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
title_full_unstemmed Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
title_short Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
title_sort sulfated glucan from the green seaweed caulerpa sertularioides inhibits adipogenesis through suppression of adipogenic and lipogenic key factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331110/
https://www.ncbi.nlm.nih.gov/pubmed/35892938
http://dx.doi.org/10.3390/md20080470
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