Cargando…

Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania

(1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional study was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest CT and laboratory analy...

Descripción completa

Detalles Bibliográficos
Autores principales: Citu, Cosmin, Gorun, Oana Maria, Motoc, Andrei, Citu, Ioana Mihaela, Gorun, Florin, Malita, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331121/
https://www.ncbi.nlm.nih.gov/pubmed/35893392
http://dx.doi.org/10.3390/jcm11154299
_version_ 1784758326060384256
author Citu, Cosmin
Gorun, Oana Maria
Motoc, Andrei
Citu, Ioana Mihaela
Gorun, Florin
Malita, Daniel
author_facet Citu, Cosmin
Gorun, Oana Maria
Motoc, Andrei
Citu, Ioana Mihaela
Gorun, Florin
Malita, Daniel
author_sort Citu, Cosmin
collection PubMed
description (1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional study was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest CT and laboratory analysis were performed in all patients. The rank Spearmen correlation was used to assess the association between inflammatory markers and lung involvement. In addition, ROC curve analysis was used to determine the accuracy of inflammatory markers in the diagnosis of severe lung damage; (3) Results: CRP, NLR, and IL-6 were significantly positively correlated with lung damage. All inflammatory markers had good accuracy for diagnosis of severe lung involvement. Moreover, IL-6 has the highest AUC- ROC curve; (4) Conclusions: The inflammatory markers are associated with lung damage and can be used to evaluate COVID-19 severity.
format Online
Article
Text
id pubmed-9331121
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93311212022-07-29 Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania Citu, Cosmin Gorun, Oana Maria Motoc, Andrei Citu, Ioana Mihaela Gorun, Florin Malita, Daniel J Clin Med Article (1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional study was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest CT and laboratory analysis were performed in all patients. The rank Spearmen correlation was used to assess the association between inflammatory markers and lung involvement. In addition, ROC curve analysis was used to determine the accuracy of inflammatory markers in the diagnosis of severe lung damage; (3) Results: CRP, NLR, and IL-6 were significantly positively correlated with lung damage. All inflammatory markers had good accuracy for diagnosis of severe lung involvement. Moreover, IL-6 has the highest AUC- ROC curve; (4) Conclusions: The inflammatory markers are associated with lung damage and can be used to evaluate COVID-19 severity. MDPI 2022-07-25 /pmc/articles/PMC9331121/ /pubmed/35893392 http://dx.doi.org/10.3390/jcm11154299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Citu, Cosmin
Gorun, Oana Maria
Motoc, Andrei
Citu, Ioana Mihaela
Gorun, Florin
Malita, Daniel
Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
title Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
title_full Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
title_fullStr Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
title_full_unstemmed Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
title_short Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
title_sort correlation of lung damage on ct scan with laboratory inflammatory markers in covid-19 patients: a single-center study from romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331121/
https://www.ncbi.nlm.nih.gov/pubmed/35893392
http://dx.doi.org/10.3390/jcm11154299
work_keys_str_mv AT citucosmin correlationoflungdamageonctscanwithlaboratoryinflammatorymarkersincovid19patientsasinglecenterstudyfromromania
AT gorunoanamaria correlationoflungdamageonctscanwithlaboratoryinflammatorymarkersincovid19patientsasinglecenterstudyfromromania
AT motocandrei correlationoflungdamageonctscanwithlaboratoryinflammatorymarkersincovid19patientsasinglecenterstudyfromromania
AT cituioanamihaela correlationoflungdamageonctscanwithlaboratoryinflammatorymarkersincovid19patientsasinglecenterstudyfromromania
AT gorunflorin correlationoflungdamageonctscanwithlaboratoryinflammatorymarkersincovid19patientsasinglecenterstudyfromromania
AT malitadaniel correlationoflungdamageonctscanwithlaboratoryinflammatorymarkersincovid19patientsasinglecenterstudyfromromania