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Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo

This study is designed to investigate the effects of increased progesterone (P4) levels on the quality of retrieved oocytes and embryos during IVF. This retrospective analysis included 982 all-freezing in vitro fertilization (IVF) cycles (conducted between November 2019 and June 2020 at CHA Fertilit...

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Autores principales: Woo, Jeesoo, Kwon, Hwang, Choi, Donghee, Park, Chan, Kim, Jihyang, Shin, Jieun, Kim, Jeehyun, Kang, Youn-Jung, Koo, Hwaseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331243/
https://www.ncbi.nlm.nih.gov/pubmed/35893410
http://dx.doi.org/10.3390/jcm11154319
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author Woo, Jeesoo
Kwon, Hwang
Choi, Donghee
Park, Chan
Kim, Jihyang
Shin, Jieun
Kim, Jeehyun
Kang, Youn-Jung
Koo, Hwaseon
author_facet Woo, Jeesoo
Kwon, Hwang
Choi, Donghee
Park, Chan
Kim, Jihyang
Shin, Jieun
Kim, Jeehyun
Kang, Youn-Jung
Koo, Hwaseon
author_sort Woo, Jeesoo
collection PubMed
description This study is designed to investigate the effects of increased progesterone (P4) levels on the quality of retrieved oocytes and embryos during IVF. This retrospective analysis included 982 all-freezing in vitro fertilization (IVF) cycles (conducted between November 2019 and June 2020 at CHA Fertility Center Bundang, South Korea) in which serum P4 levels were measured on the day of human chorionic gonadotropin (hCG) administration. Our study revealed that the serum P4 levels on the day of hCG administration are strongly associated with the rates of oocyte maturation, displaying a positive correlation in patients with serum P4 < 2.25 ng/mL (p = 0.025). Moreover, patients with serum P4 < 1.25 ng/mL showed relatively low fertilization rates (p = 0.037), and the rates of good embryo retrieval were significantly increased with the serum P4 level < 1.5 ng/mL (p = 0.001). Interestingly, serum P4 level on the day of hCG administration affects the rate of good-quality embryo development, especially at the cleavage stage, and is associated with the status of ovarian responses. Our current study suggests that serum P4 level on the day of hCG administration negatively affects the rates of oocyte maturation, fertilization, and the development of good embryos.
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spelling pubmed-93312432022-07-29 Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo Woo, Jeesoo Kwon, Hwang Choi, Donghee Park, Chan Kim, Jihyang Shin, Jieun Kim, Jeehyun Kang, Youn-Jung Koo, Hwaseon J Clin Med Article This study is designed to investigate the effects of increased progesterone (P4) levels on the quality of retrieved oocytes and embryos during IVF. This retrospective analysis included 982 all-freezing in vitro fertilization (IVF) cycles (conducted between November 2019 and June 2020 at CHA Fertility Center Bundang, South Korea) in which serum P4 levels were measured on the day of human chorionic gonadotropin (hCG) administration. Our study revealed that the serum P4 levels on the day of hCG administration are strongly associated with the rates of oocyte maturation, displaying a positive correlation in patients with serum P4 < 2.25 ng/mL (p = 0.025). Moreover, patients with serum P4 < 1.25 ng/mL showed relatively low fertilization rates (p = 0.037), and the rates of good embryo retrieval were significantly increased with the serum P4 level < 1.5 ng/mL (p = 0.001). Interestingly, serum P4 level on the day of hCG administration affects the rate of good-quality embryo development, especially at the cleavage stage, and is associated with the status of ovarian responses. Our current study suggests that serum P4 level on the day of hCG administration negatively affects the rates of oocyte maturation, fertilization, and the development of good embryos. MDPI 2022-07-25 /pmc/articles/PMC9331243/ /pubmed/35893410 http://dx.doi.org/10.3390/jcm11154319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Woo, Jeesoo
Kwon, Hwang
Choi, Donghee
Park, Chan
Kim, Jihyang
Shin, Jieun
Kim, Jeehyun
Kang, Youn-Jung
Koo, Hwaseon
Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo
title Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo
title_full Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo
title_fullStr Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo
title_full_unstemmed Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo
title_short Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo
title_sort effects of elevated progesterone levels on the day of hcg on the quality of oocyte and embryo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331243/
https://www.ncbi.nlm.nih.gov/pubmed/35893410
http://dx.doi.org/10.3390/jcm11154319
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