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Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions

Background and Objectives: Pancreatic cystic lesions (PCLs) are frequently incidental findings. The prevalence of PCLs is increasing, mainly due to advancements in imaging techniques, but also because of the aging of the population. PCLs comprise challenging clinical problems, as their manifestation...

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Autores principales: Wietrzykowska-Grishanovich, Dominika, Pawlik, Ewa, Neubauer, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331360/
https://www.ncbi.nlm.nih.gov/pubmed/35893110
http://dx.doi.org/10.3390/medicina58080994
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author Wietrzykowska-Grishanovich, Dominika
Pawlik, Ewa
Neubauer, Katarzyna
author_facet Wietrzykowska-Grishanovich, Dominika
Pawlik, Ewa
Neubauer, Katarzyna
author_sort Wietrzykowska-Grishanovich, Dominika
collection PubMed
description Background and Objectives: Pancreatic cystic lesions (PCLs) are frequently incidental findings. The prevalence of PCLs is increasing, mainly due to advancements in imaging techniques, but also because of the aging of the population. PCLs comprise challenging clinical problems, as their manifestations vary from benign to malignant lesions. Therefore, the recognition of PCLs is achieved through a complex diagnostic and surveillance process, which in turn is usually long-term, invasive, and expensive. Despite the progress made in the identification of novel biomarkers in the cystic fluid that also support the differentiation of PCLs, their application in clinical practice is limited. Materials and Methods: We conducted a systematic review of the literature published in two databases, Pubmed and Embase, on biochemical biomarkers in PCLs that may be applied in the diagnostic algorithms of PCLs. Results: Eleven studies on intracystic glucose, twenty studies on intracystic carcinoembryonic antigen (CEA), and eighteen studies on other biomarkers were identified. Low levels of intracystic glucose had high sensitivity and specificity in the differentiation between mucinous and non-mucinous cystic neoplasms. Conclusions: CEA and glucose are the most widely studied fluid biochemical markers in pancreatic cystic lesions. Glucose has better diagnostic accuracy than CEA. Other biochemical biomarkers require further research.
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spelling pubmed-93313602022-07-29 Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions Wietrzykowska-Grishanovich, Dominika Pawlik, Ewa Neubauer, Katarzyna Medicina (Kaunas) Systematic Review Background and Objectives: Pancreatic cystic lesions (PCLs) are frequently incidental findings. The prevalence of PCLs is increasing, mainly due to advancements in imaging techniques, but also because of the aging of the population. PCLs comprise challenging clinical problems, as their manifestations vary from benign to malignant lesions. Therefore, the recognition of PCLs is achieved through a complex diagnostic and surveillance process, which in turn is usually long-term, invasive, and expensive. Despite the progress made in the identification of novel biomarkers in the cystic fluid that also support the differentiation of PCLs, their application in clinical practice is limited. Materials and Methods: We conducted a systematic review of the literature published in two databases, Pubmed and Embase, on biochemical biomarkers in PCLs that may be applied in the diagnostic algorithms of PCLs. Results: Eleven studies on intracystic glucose, twenty studies on intracystic carcinoembryonic antigen (CEA), and eighteen studies on other biomarkers were identified. Low levels of intracystic glucose had high sensitivity and specificity in the differentiation between mucinous and non-mucinous cystic neoplasms. Conclusions: CEA and glucose are the most widely studied fluid biochemical markers in pancreatic cystic lesions. Glucose has better diagnostic accuracy than CEA. Other biochemical biomarkers require further research. MDPI 2022-07-26 /pmc/articles/PMC9331360/ /pubmed/35893110 http://dx.doi.org/10.3390/medicina58080994 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Wietrzykowska-Grishanovich, Dominika
Pawlik, Ewa
Neubauer, Katarzyna
Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions
title Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions
title_full Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions
title_fullStr Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions
title_full_unstemmed Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions
title_short Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions
title_sort biochemical intracystic biomarkers in the differential diagnosis of pancreatic cystic lesions
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331360/
https://www.ncbi.nlm.nih.gov/pubmed/35893110
http://dx.doi.org/10.3390/medicina58080994
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