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Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)

Background: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been little-st...

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Autores principales: Huang, Jue, Mauche, Nicole, Rullmann, Michael, Ulke, Christine, Becker, Georg-Alexander, Patt, Marianne, Zientek, Franziska, Hesse, Swen, Sabri, Osama, Strauß, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331391/
https://www.ncbi.nlm.nih.gov/pubmed/35892406
http://dx.doi.org/10.3390/brainsci12080965
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author Huang, Jue
Mauche, Nicole
Rullmann, Michael
Ulke, Christine
Becker, Georg-Alexander
Patt, Marianne
Zientek, Franziska
Hesse, Swen
Sabri, Osama
Strauß, Maria
author_facet Huang, Jue
Mauche, Nicole
Rullmann, Michael
Ulke, Christine
Becker, Georg-Alexander
Patt, Marianne
Zientek, Franziska
Hesse, Swen
Sabri, Osama
Strauß, Maria
author_sort Huang, Jue
collection PubMed
description Background: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been little-studied. This follow-up research on adult patients with ADHD aimed to explore whether the therapy response and health and social impairments depend on baseline individual NET availability. Methods: Data were collected from 10 patients on personal, family and professional situations, mental and physical health and treatments received after baseline via online and telephone surveys and were compared to baseline data to evaluate treatment-related changes. Results: The majority of our ADHD patients did not show therapy responses but showed improvements due to pharmacological treatment. There was no evidence of relationships between pre-treatment NET availability and therapy response or health/social limitations. Conclusions: Pharmacological monotherapy was insufficient to promote symptom remission, especially for participants with extreme insufficiency in NET availability, but improved outcomes in academic and social functioning. Psychotherapy should be considered as an add-on to the standard treatment approach due to its positive outcome in reducing social limitations. The prognostic value of individual NET availability in predicting the response to therapy needs further studies with large sample sizes.
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spelling pubmed-93313912022-07-29 Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) Huang, Jue Mauche, Nicole Rullmann, Michael Ulke, Christine Becker, Georg-Alexander Patt, Marianne Zientek, Franziska Hesse, Swen Sabri, Osama Strauß, Maria Brain Sci Article Background: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been little-studied. This follow-up research on adult patients with ADHD aimed to explore whether the therapy response and health and social impairments depend on baseline individual NET availability. Methods: Data were collected from 10 patients on personal, family and professional situations, mental and physical health and treatments received after baseline via online and telephone surveys and were compared to baseline data to evaluate treatment-related changes. Results: The majority of our ADHD patients did not show therapy responses but showed improvements due to pharmacological treatment. There was no evidence of relationships between pre-treatment NET availability and therapy response or health/social limitations. Conclusions: Pharmacological monotherapy was insufficient to promote symptom remission, especially for participants with extreme insufficiency in NET availability, but improved outcomes in academic and social functioning. Psychotherapy should be considered as an add-on to the standard treatment approach due to its positive outcome in reducing social limitations. The prognostic value of individual NET availability in predicting the response to therapy needs further studies with large sample sizes. MDPI 2022-07-22 /pmc/articles/PMC9331391/ /pubmed/35892406 http://dx.doi.org/10.3390/brainsci12080965 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Jue
Mauche, Nicole
Rullmann, Michael
Ulke, Christine
Becker, Georg-Alexander
Patt, Marianne
Zientek, Franziska
Hesse, Swen
Sabri, Osama
Strauß, Maria
Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
title Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
title_full Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
title_fullStr Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
title_full_unstemmed Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
title_short Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
title_sort association between individual norepinephrine transporter (net) availability and response to pharmacological therapy in adults with attention-deficit/hyperactivity disorder (adhd)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331391/
https://www.ncbi.nlm.nih.gov/pubmed/35892406
http://dx.doi.org/10.3390/brainsci12080965
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