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Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted mainly in the brain and adipose tissue, is bein...

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Autores principales: Vergani, Edoardo, Bruno, Carmine, Cipolla, Clelia, Currò, Diego, Mancini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331476/
https://www.ncbi.nlm.nih.gov/pubmed/35909572
http://dx.doi.org/10.3389/fendo.2022.881524
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author Vergani, Edoardo
Bruno, Carmine
Cipolla, Clelia
Currò, Diego
Mancini, Antonio
author_facet Vergani, Edoardo
Bruno, Carmine
Cipolla, Clelia
Currò, Diego
Mancini, Antonio
author_sort Vergani, Edoardo
collection PubMed
description Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted mainly in the brain and adipose tissue, is being investigated for its possible activity as a negative regulator of energy expenditure. We conducted a cross-sectional observational preliminary study with the aim of testing the hypothesis that plasma levels of neudesin can be modified in obese and overweight children and to evaluate any possible relationship between plasma neudesin levels and metabolic and anthropometric parameters. 34 Children (Tanner’s stage 1) were included and divided in two groups according to Cole’s criteria. Group A included obese and overweight children (23 patients, 17 females and 6 males, aged 4-10 years); Group B included healthy normal-weight children (11 subjects, 7 females and 4 males, aged 3-10 years). Metabolic (glucose and insulin, total, LDL- and HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters were evaluated. HOMA-IR and QUICKI index and the area under the curve (AUC) of glucose and insulin after oral glucose load were calculated in obese and overweight children. Neudesin was measured by ELISA. Neudesin levels were significantly higher in obese/overweight children than in controls. In obese and overweight children, plasma neudesin levels were significantly directly correlated with blood glucose and glucose AUC. Taken together, these results, although preliminary, may suggest a possible age-related role of neudesin in glucose homeostasis in obese/overweight children.
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spelling pubmed-93314762022-07-29 Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children Vergani, Edoardo Bruno, Carmine Cipolla, Clelia Currò, Diego Mancini, Antonio Front Endocrinol (Lausanne) Endocrinology Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted mainly in the brain and adipose tissue, is being investigated for its possible activity as a negative regulator of energy expenditure. We conducted a cross-sectional observational preliminary study with the aim of testing the hypothesis that plasma levels of neudesin can be modified in obese and overweight children and to evaluate any possible relationship between plasma neudesin levels and metabolic and anthropometric parameters. 34 Children (Tanner’s stage 1) were included and divided in two groups according to Cole’s criteria. Group A included obese and overweight children (23 patients, 17 females and 6 males, aged 4-10 years); Group B included healthy normal-weight children (11 subjects, 7 females and 4 males, aged 3-10 years). Metabolic (glucose and insulin, total, LDL- and HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters were evaluated. HOMA-IR and QUICKI index and the area under the curve (AUC) of glucose and insulin after oral glucose load were calculated in obese and overweight children. Neudesin was measured by ELISA. Neudesin levels were significantly higher in obese/overweight children than in controls. In obese and overweight children, plasma neudesin levels were significantly directly correlated with blood glucose and glucose AUC. Taken together, these results, although preliminary, may suggest a possible age-related role of neudesin in glucose homeostasis in obese/overweight children. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9331476/ /pubmed/35909572 http://dx.doi.org/10.3389/fendo.2022.881524 Text en Copyright © 2022 Vergani, Bruno, Cipolla, Currò and Mancini https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Vergani, Edoardo
Bruno, Carmine
Cipolla, Clelia
Currò, Diego
Mancini, Antonio
Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children
title Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children
title_full Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children
title_fullStr Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children
title_full_unstemmed Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children
title_short Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children
title_sort plasma levels of neudesin and glucose metabolism in obese and overweight children
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331476/
https://www.ncbi.nlm.nih.gov/pubmed/35909572
http://dx.doi.org/10.3389/fendo.2022.881524
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