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The serotonergic system dysfunction in diabetes mellitus

Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in various non-neuronal and neuronal systems. In the central nervous system, it functions as a neurotransmitter to modulate feeding...

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Autores principales: Cai, Yan, Li, Xiaolong, Zhou, Hongli, Zhou, Jiyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331500/
https://www.ncbi.nlm.nih.gov/pubmed/35910256
http://dx.doi.org/10.3389/fncel.2022.899069
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author Cai, Yan
Li, Xiaolong
Zhou, Hongli
Zhou, Jiyin
author_facet Cai, Yan
Li, Xiaolong
Zhou, Hongli
Zhou, Jiyin
author_sort Cai, Yan
collection PubMed
description Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in various non-neuronal and neuronal systems. In the central nervous system, it functions as a neurotransmitter to modulate feeding behavior and mood. Numerous clinical trials have focused on increasing 5-HT activation in the central nervous system, including those involving anti-obesity drugs currently in the market, although severe side effects on peripheral system can lead to the withdrawal of certain drugs. Recent studies have revealed that both the peripheral and central serotonergic systems play a vital role in diabetes and its complications. This review summarizes the roles of the serotonergic system in blood glucose regulation, diabetic macroangiopathy, diabetic peripheral neuropathy, and diabetic encephalopathy, indicating its potential clinical significance as a therapeutic target for the treatment of diabetes and its complications.
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spelling pubmed-93315002022-07-29 The serotonergic system dysfunction in diabetes mellitus Cai, Yan Li, Xiaolong Zhou, Hongli Zhou, Jiyin Front Cell Neurosci Cellular Neuroscience Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in various non-neuronal and neuronal systems. In the central nervous system, it functions as a neurotransmitter to modulate feeding behavior and mood. Numerous clinical trials have focused on increasing 5-HT activation in the central nervous system, including those involving anti-obesity drugs currently in the market, although severe side effects on peripheral system can lead to the withdrawal of certain drugs. Recent studies have revealed that both the peripheral and central serotonergic systems play a vital role in diabetes and its complications. This review summarizes the roles of the serotonergic system in blood glucose regulation, diabetic macroangiopathy, diabetic peripheral neuropathy, and diabetic encephalopathy, indicating its potential clinical significance as a therapeutic target for the treatment of diabetes and its complications. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9331500/ /pubmed/35910256 http://dx.doi.org/10.3389/fncel.2022.899069 Text en Copyright © 2022 Cai, Li, Zhou and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Cai, Yan
Li, Xiaolong
Zhou, Hongli
Zhou, Jiyin
The serotonergic system dysfunction in diabetes mellitus
title The serotonergic system dysfunction in diabetes mellitus
title_full The serotonergic system dysfunction in diabetes mellitus
title_fullStr The serotonergic system dysfunction in diabetes mellitus
title_full_unstemmed The serotonergic system dysfunction in diabetes mellitus
title_short The serotonergic system dysfunction in diabetes mellitus
title_sort serotonergic system dysfunction in diabetes mellitus
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331500/
https://www.ncbi.nlm.nih.gov/pubmed/35910256
http://dx.doi.org/10.3389/fncel.2022.899069
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