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Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms

A detailed knowledge of the status of the retina in neurodegenerative conditions is a crucial point for the development of therapeutics in retinal pathologies and to translate eye research to CNS disease. In this context, manipulating signaling pathways that lead to neuronal regeneration offers an e...

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Detalles Bibliográficos
Autores principales: Catalani, Elisabetta, Cherubini, Agnese, Del Quondam, Simona, Cervia, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331597/
https://www.ncbi.nlm.nih.gov/pubmed/35897754
http://dx.doi.org/10.3390/ijms23158180
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author Catalani, Elisabetta
Cherubini, Agnese
Del Quondam, Simona
Cervia, Davide
author_facet Catalani, Elisabetta
Cherubini, Agnese
Del Quondam, Simona
Cervia, Davide
author_sort Catalani, Elisabetta
collection PubMed
description A detailed knowledge of the status of the retina in neurodegenerative conditions is a crucial point for the development of therapeutics in retinal pathologies and to translate eye research to CNS disease. In this context, manipulating signaling pathways that lead to neuronal regeneration offers an excellent opportunity to substitute damaged cells and, thus, restore the tissue functionality. Alternative systems and methods are increasingly being considered to replace/reduce in vivo approaches in the study of retina pathophysiology. Herein, we present recent data obtained from the zebrafish (Danio rerio) and the fruit fly Drosophila melanogaster that bring promising advantages into studying and modeling, at a preclinical level, neurodegeneration and regenerative approaches in retinal diseases. Indeed, the regenerative ability of vertebrate model zebrafish is particularly appealing. In addition, the fruit fly is ideal for regenerative studies due to its high degree of conservation with vertebrates and the broad spectrum of genetic variants achievable. Furthermore, a large part of the drosophila brain is dedicated to sight, thus offering the possibility of studying common mechanisms of the visual system and the brain at once. The knowledge acquired from these alternative models may help to investigate specific well-conserved factors of interest in human neuroregeneration after injuries or during pathologies.
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spelling pubmed-93315972022-07-29 Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms Catalani, Elisabetta Cherubini, Agnese Del Quondam, Simona Cervia, Davide Int J Mol Sci Review A detailed knowledge of the status of the retina in neurodegenerative conditions is a crucial point for the development of therapeutics in retinal pathologies and to translate eye research to CNS disease. In this context, manipulating signaling pathways that lead to neuronal regeneration offers an excellent opportunity to substitute damaged cells and, thus, restore the tissue functionality. Alternative systems and methods are increasingly being considered to replace/reduce in vivo approaches in the study of retina pathophysiology. Herein, we present recent data obtained from the zebrafish (Danio rerio) and the fruit fly Drosophila melanogaster that bring promising advantages into studying and modeling, at a preclinical level, neurodegeneration and regenerative approaches in retinal diseases. Indeed, the regenerative ability of vertebrate model zebrafish is particularly appealing. In addition, the fruit fly is ideal for regenerative studies due to its high degree of conservation with vertebrates and the broad spectrum of genetic variants achievable. Furthermore, a large part of the drosophila brain is dedicated to sight, thus offering the possibility of studying common mechanisms of the visual system and the brain at once. The knowledge acquired from these alternative models may help to investigate specific well-conserved factors of interest in human neuroregeneration after injuries or during pathologies. MDPI 2022-07-25 /pmc/articles/PMC9331597/ /pubmed/35897754 http://dx.doi.org/10.3390/ijms23158180 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Catalani, Elisabetta
Cherubini, Agnese
Del Quondam, Simona
Cervia, Davide
Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms
title Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms
title_full Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms
title_fullStr Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms
title_full_unstemmed Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms
title_short Regenerative Strategies for Retinal Neurons: Novel Insights in Non-Mammalian Model Organisms
title_sort regenerative strategies for retinal neurons: novel insights in non-mammalian model organisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331597/
https://www.ncbi.nlm.nih.gov/pubmed/35897754
http://dx.doi.org/10.3390/ijms23158180
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