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Canadian Contributions in Fibroblast Biology
Fibroblasts are stromal cells found in virtually every tissue and organ of the body. For many years, these cells were often considered to be secondary in functional importance to parenchymal cells. Over the past 2 decades, focused research into the roles of fibroblasts has revealed important roles f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331635/ https://www.ncbi.nlm.nih.gov/pubmed/35892569 http://dx.doi.org/10.3390/cells11152272 |
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author | Al-Hattab, Danah S. Chattopadhyaya, Sikta Czubryt, Michael P. |
author_facet | Al-Hattab, Danah S. Chattopadhyaya, Sikta Czubryt, Michael P. |
author_sort | Al-Hattab, Danah S. |
collection | PubMed |
description | Fibroblasts are stromal cells found in virtually every tissue and organ of the body. For many years, these cells were often considered to be secondary in functional importance to parenchymal cells. Over the past 2 decades, focused research into the roles of fibroblasts has revealed important roles for these cells in the homeostasis of healthy tissue, and has demonstrated that activation of fibroblasts to myofibroblasts is a key step in disease initiation and progression in many tissues, with fibrosis now recognized as not only an outcome of disease, but also a central contributor to tissue dysfunction, particularly in the heart and lungs. With a growing understanding of both fibroblast and myofibroblast heterogeneity, and the deciphering of the humoral and mechanical cues that impact the phenotype of these cells, fibroblast biology is rapidly becoming a major focus in biomedical research. In this review, we provide an overview of fibroblast and myofibroblast biology, particularly in the heart, and including a discussion of pathophysiological processes such as fibrosis and scarring. We then discuss the central role of Canadian researchers in moving this field forwards, particularly in cardiac fibrosis, and highlight some of the major contributions of these individuals to our understanding of fibroblast and myofibroblast biology in health and disease. |
format | Online Article Text |
id | pubmed-9331635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93316352022-07-29 Canadian Contributions in Fibroblast Biology Al-Hattab, Danah S. Chattopadhyaya, Sikta Czubryt, Michael P. Cells Review Fibroblasts are stromal cells found in virtually every tissue and organ of the body. For many years, these cells were often considered to be secondary in functional importance to parenchymal cells. Over the past 2 decades, focused research into the roles of fibroblasts has revealed important roles for these cells in the homeostasis of healthy tissue, and has demonstrated that activation of fibroblasts to myofibroblasts is a key step in disease initiation and progression in many tissues, with fibrosis now recognized as not only an outcome of disease, but also a central contributor to tissue dysfunction, particularly in the heart and lungs. With a growing understanding of both fibroblast and myofibroblast heterogeneity, and the deciphering of the humoral and mechanical cues that impact the phenotype of these cells, fibroblast biology is rapidly becoming a major focus in biomedical research. In this review, we provide an overview of fibroblast and myofibroblast biology, particularly in the heart, and including a discussion of pathophysiological processes such as fibrosis and scarring. We then discuss the central role of Canadian researchers in moving this field forwards, particularly in cardiac fibrosis, and highlight some of the major contributions of these individuals to our understanding of fibroblast and myofibroblast biology in health and disease. MDPI 2022-07-23 /pmc/articles/PMC9331635/ /pubmed/35892569 http://dx.doi.org/10.3390/cells11152272 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Al-Hattab, Danah S. Chattopadhyaya, Sikta Czubryt, Michael P. Canadian Contributions in Fibroblast Biology |
title | Canadian Contributions in Fibroblast Biology |
title_full | Canadian Contributions in Fibroblast Biology |
title_fullStr | Canadian Contributions in Fibroblast Biology |
title_full_unstemmed | Canadian Contributions in Fibroblast Biology |
title_short | Canadian Contributions in Fibroblast Biology |
title_sort | canadian contributions in fibroblast biology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331635/ https://www.ncbi.nlm.nih.gov/pubmed/35892569 http://dx.doi.org/10.3390/cells11152272 |
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