A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation

Atrial arrhythmias are common in patients with diabetes mellitus (DM), and despite recent advances in pharmaceutical and invasive treatments, atrial fibrillation (AF) and atrial flutter (AFl) are still associated with substantial mortality and morbidity. Clinical trial data imply a protective effect...

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Detalles Bibliográficos
Autores principales: Karamichalakis, Nikolaos, Kolovos, Vasileios, Paraskevaidis, Ioannis, Tsougos, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331782/
https://www.ncbi.nlm.nih.gov/pubmed/35893226
http://dx.doi.org/10.3390/jcdd9080236
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author Karamichalakis, Nikolaos
Kolovos, Vasileios
Paraskevaidis, Ioannis
Tsougos, Elias
author_facet Karamichalakis, Nikolaos
Kolovos, Vasileios
Paraskevaidis, Ioannis
Tsougos, Elias
author_sort Karamichalakis, Nikolaos
collection PubMed
description Atrial arrhythmias are common in patients with diabetes mellitus (DM), and despite recent advances in pharmaceutical and invasive treatments, atrial fibrillation (AF) and atrial flutter (AFl) are still associated with substantial mortality and morbidity. Clinical trial data imply a protective effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on the occurrence of AF and AFl. This review summarizes the state of knowledge regarding DM-mediated mechanisms responsible for AF genesis and recurrence but also discusses the recent data from experimental studies, published trials and metanalyses.
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spelling pubmed-93317822022-07-29 A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation Karamichalakis, Nikolaos Kolovos, Vasileios Paraskevaidis, Ioannis Tsougos, Elias J Cardiovasc Dev Dis Review Atrial arrhythmias are common in patients with diabetes mellitus (DM), and despite recent advances in pharmaceutical and invasive treatments, atrial fibrillation (AF) and atrial flutter (AFl) are still associated with substantial mortality and morbidity. Clinical trial data imply a protective effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on the occurrence of AF and AFl. This review summarizes the state of knowledge regarding DM-mediated mechanisms responsible for AF genesis and recurrence but also discusses the recent data from experimental studies, published trials and metanalyses. MDPI 2022-07-26 /pmc/articles/PMC9331782/ /pubmed/35893226 http://dx.doi.org/10.3390/jcdd9080236 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Karamichalakis, Nikolaos
Kolovos, Vasileios
Paraskevaidis, Ioannis
Tsougos, Elias
A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation
title A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation
title_full A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation
title_fullStr A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation
title_full_unstemmed A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation
title_short A New Hope: Sodium-Glucose Cotransporter-2 Inhibition to Prevent Atrial Fibrillation
title_sort new hope: sodium-glucose cotransporter-2 inhibition to prevent atrial fibrillation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331782/
https://www.ncbi.nlm.nih.gov/pubmed/35893226
http://dx.doi.org/10.3390/jcdd9080236
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