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Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitocho...

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Autores principales: Alarcon-Gil, Jesus, Sierra-Magro, Ana, Morales-Garcia, Jose A., Sanz-SanCristobal, Marina, Alonso-Gil, Sandra, Cortes-Canteli, Marta, Niso-Santano, Mireia, Martínez-Chacón, Guadalupe, Fuentes, Jose M., Santos, Angel, Perez-Castillo, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331796/
https://www.ncbi.nlm.nih.gov/pubmed/35892594
http://dx.doi.org/10.3390/cells11152297
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author Alarcon-Gil, Jesus
Sierra-Magro, Ana
Morales-Garcia, Jose A.
Sanz-SanCristobal, Marina
Alonso-Gil, Sandra
Cortes-Canteli, Marta
Niso-Santano, Mireia
Martínez-Chacón, Guadalupe
Fuentes, Jose M.
Santos, Angel
Perez-Castillo, Ana
author_facet Alarcon-Gil, Jesus
Sierra-Magro, Ana
Morales-Garcia, Jose A.
Sanz-SanCristobal, Marina
Alonso-Gil, Sandra
Cortes-Canteli, Marta
Niso-Santano, Mireia
Martínez-Chacón, Guadalupe
Fuentes, Jose M.
Santos, Angel
Perez-Castillo, Ana
author_sort Alarcon-Gil, Jesus
collection PubMed
description Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics.
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spelling pubmed-93317962022-07-29 Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy Alarcon-Gil, Jesus Sierra-Magro, Ana Morales-Garcia, Jose A. Sanz-SanCristobal, Marina Alonso-Gil, Sandra Cortes-Canteli, Marta Niso-Santano, Mireia Martínez-Chacón, Guadalupe Fuentes, Jose M. Santos, Angel Perez-Castillo, Ana Cells Article Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics. MDPI 2022-07-26 /pmc/articles/PMC9331796/ /pubmed/35892594 http://dx.doi.org/10.3390/cells11152297 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alarcon-Gil, Jesus
Sierra-Magro, Ana
Morales-Garcia, Jose A.
Sanz-SanCristobal, Marina
Alonso-Gil, Sandra
Cortes-Canteli, Marta
Niso-Santano, Mireia
Martínez-Chacón, Guadalupe
Fuentes, Jose M.
Santos, Angel
Perez-Castillo, Ana
Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
title Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
title_full Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
title_fullStr Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
title_full_unstemmed Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
title_short Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
title_sort neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson’s disease: the implication of lipid droplets and lipophagy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331796/
https://www.ncbi.nlm.nih.gov/pubmed/35892594
http://dx.doi.org/10.3390/cells11152297
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