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Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation

Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for...

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Detalles Bibliográficos
Autores principales: Cimpoca Raptis, Brindusa Ana, Panaitescu, Anca Maria, Peltecu, Gheorghe, Gica, Nicolae, Botezatu, Radu, Popescu, Mihaela Roxana, Macri, Anca, Constantin, Ana, Pavel, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331898/
https://www.ncbi.nlm.nih.gov/pubmed/35893099
http://dx.doi.org/10.3390/medicina58080984
Descripción
Sumario:Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome.