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Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients

Evidence for clinical screening and intervention for depression in cancer and the effect of this intervention on cancer prognosis is suboptimal. This study substantialized a complete model with universal screening and intervention for major depressive disorder (MDD) and explored its effect on surviv...

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Autores principales: Yen, Yung-Chieh, Huang, Chin-Yu, Chan, Hsue-Wei, Wang, You-Yu, Changchien, Te-Chang, Wang, Deng-Wu, Lin, Po-Chun, Chang, Ting-Ting, Chiu, Yu-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331985/
https://www.ncbi.nlm.nih.gov/pubmed/35893308
http://dx.doi.org/10.3390/jpm12081213
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author Yen, Yung-Chieh
Huang, Chin-Yu
Chan, Hsue-Wei
Wang, You-Yu
Changchien, Te-Chang
Wang, Deng-Wu
Lin, Po-Chun
Chang, Ting-Ting
Chiu, Yu-Wen
author_facet Yen, Yung-Chieh
Huang, Chin-Yu
Chan, Hsue-Wei
Wang, You-Yu
Changchien, Te-Chang
Wang, Deng-Wu
Lin, Po-Chun
Chang, Ting-Ting
Chiu, Yu-Wen
author_sort Yen, Yung-Chieh
collection PubMed
description Evidence for clinical screening and intervention for depression in cancer and the effect of this intervention on cancer prognosis is suboptimal. This study substantialized a complete model with universal screening and intervention for major depressive disorder (MDD) and explored its effect on survival in patients. This longitudinal study recruited cancer patients routinely screened for MDD with a two-stage model. Data including sex, age, cancer diagnosis, first diagnosis date, date of death, cancer stage, and MDD diagnosis and treatment were collected from medical records and the national registration system for cancer. Kaplan–Meier’s survival analysis and the Cox proportional hazards regression model were applied to analyze the effects of associated factors on survival. Further subgroup analysis for 14 types of cancer primary site was also performed. Overall, the hazard for patients adhering to psychiatric treatment for MDD before cancer diagnosis was not statistically different from that for patients without MDD (hazard ratio (HR) = 1.061, 95% CI: 0.889–1.267, p = 0.512). The hazard for patients adhering to psychiatric treatment after cancer diagnosis was significantly lower than that for patients without MDD (HR = 0.702, 95% CI: 0.607–0.812, p < 0.001). Those who were diagnosed with MDD after cancer diagnosis and adhered poorly to psychiatric treatment had the greatest hazard (HR = 1.829, 95% CI: 1.687–1.984, p < 0.001). The effect of intervention for MDD varied across different primary cancer types.
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spelling pubmed-93319852022-07-29 Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients Yen, Yung-Chieh Huang, Chin-Yu Chan, Hsue-Wei Wang, You-Yu Changchien, Te-Chang Wang, Deng-Wu Lin, Po-Chun Chang, Ting-Ting Chiu, Yu-Wen J Pers Med Article Evidence for clinical screening and intervention for depression in cancer and the effect of this intervention on cancer prognosis is suboptimal. This study substantialized a complete model with universal screening and intervention for major depressive disorder (MDD) and explored its effect on survival in patients. This longitudinal study recruited cancer patients routinely screened for MDD with a two-stage model. Data including sex, age, cancer diagnosis, first diagnosis date, date of death, cancer stage, and MDD diagnosis and treatment were collected from medical records and the national registration system for cancer. Kaplan–Meier’s survival analysis and the Cox proportional hazards regression model were applied to analyze the effects of associated factors on survival. Further subgroup analysis for 14 types of cancer primary site was also performed. Overall, the hazard for patients adhering to psychiatric treatment for MDD before cancer diagnosis was not statistically different from that for patients without MDD (hazard ratio (HR) = 1.061, 95% CI: 0.889–1.267, p = 0.512). The hazard for patients adhering to psychiatric treatment after cancer diagnosis was significantly lower than that for patients without MDD (HR = 0.702, 95% CI: 0.607–0.812, p < 0.001). Those who were diagnosed with MDD after cancer diagnosis and adhered poorly to psychiatric treatment had the greatest hazard (HR = 1.829, 95% CI: 1.687–1.984, p < 0.001). The effect of intervention for MDD varied across different primary cancer types. MDPI 2022-07-26 /pmc/articles/PMC9331985/ /pubmed/35893308 http://dx.doi.org/10.3390/jpm12081213 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yen, Yung-Chieh
Huang, Chin-Yu
Chan, Hsue-Wei
Wang, You-Yu
Changchien, Te-Chang
Wang, Deng-Wu
Lin, Po-Chun
Chang, Ting-Ting
Chiu, Yu-Wen
Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients
title Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients
title_full Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients
title_fullStr Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients
title_full_unstemmed Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients
title_short Longitudinal Association of Universal Screening and Treatment for Major Depressive Disorder with Survival in Cancer Patients
title_sort longitudinal association of universal screening and treatment for major depressive disorder with survival in cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331985/
https://www.ncbi.nlm.nih.gov/pubmed/35893308
http://dx.doi.org/10.3390/jpm12081213
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