An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer

Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for patients with microsatellites instability/mismatch rep...

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Autores principales: Bartoletti, Michele, Giorda, Giorgio, Viel, Alessandra, Fornasarig, Mara, Zdjelar, Adrian, Segatto, Enrica, Sorio, Roberto, Corsetti, Serena, Scalone, Simona, Nicoloso, Milena Sabrina, Pivetta, Tania, Lucia, Emilio, Clemente, Nicolò, Palazzari, Elisa, Canzonieri, Vincenzo, Puglisi, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332114/
https://www.ncbi.nlm.nih.gov/pubmed/35892982
http://dx.doi.org/10.3390/curroncol29080413
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author Bartoletti, Michele
Giorda, Giorgio
Viel, Alessandra
Fornasarig, Mara
Zdjelar, Adrian
Segatto, Enrica
Sorio, Roberto
Corsetti, Serena
Scalone, Simona
Nicoloso, Milena Sabrina
Pivetta, Tania
Lucia, Emilio
Clemente, Nicolò
Palazzari, Elisa
Canzonieri, Vincenzo
Puglisi, Fabio
author_facet Bartoletti, Michele
Giorda, Giorgio
Viel, Alessandra
Fornasarig, Mara
Zdjelar, Adrian
Segatto, Enrica
Sorio, Roberto
Corsetti, Serena
Scalone, Simona
Nicoloso, Milena Sabrina
Pivetta, Tania
Lucia, Emilio
Clemente, Nicolò
Palazzari, Elisa
Canzonieri, Vincenzo
Puglisi, Fabio
author_sort Bartoletti, Michele
collection PubMed
description Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for patients with microsatellites instability/mismatch repair deficiency. In this case report, we describe an exceptional and rapid response to dostarlimab in a platinum refractory endometrial cancer patient with high disease burden harboring a mismatch repair deficiency.
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spelling pubmed-93321142022-07-29 An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer Bartoletti, Michele Giorda, Giorgio Viel, Alessandra Fornasarig, Mara Zdjelar, Adrian Segatto, Enrica Sorio, Roberto Corsetti, Serena Scalone, Simona Nicoloso, Milena Sabrina Pivetta, Tania Lucia, Emilio Clemente, Nicolò Palazzari, Elisa Canzonieri, Vincenzo Puglisi, Fabio Curr Oncol Case Report Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for patients with microsatellites instability/mismatch repair deficiency. In this case report, we describe an exceptional and rapid response to dostarlimab in a platinum refractory endometrial cancer patient with high disease burden harboring a mismatch repair deficiency. MDPI 2022-07-22 /pmc/articles/PMC9332114/ /pubmed/35892982 http://dx.doi.org/10.3390/curroncol29080413 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bartoletti, Michele
Giorda, Giorgio
Viel, Alessandra
Fornasarig, Mara
Zdjelar, Adrian
Segatto, Enrica
Sorio, Roberto
Corsetti, Serena
Scalone, Simona
Nicoloso, Milena Sabrina
Pivetta, Tania
Lucia, Emilio
Clemente, Nicolò
Palazzari, Elisa
Canzonieri, Vincenzo
Puglisi, Fabio
An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
title An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
title_full An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
title_fullStr An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
title_full_unstemmed An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
title_short An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
title_sort exceptional response to dostarlimab in mismatch repair deficient, microsatellite instability-high and platinum refractory endometrial cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332114/
https://www.ncbi.nlm.nih.gov/pubmed/35892982
http://dx.doi.org/10.3390/curroncol29080413
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