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Maternal High-Fat Diet and Offspring Hypertension
The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332200/ https://www.ncbi.nlm.nih.gov/pubmed/35897755 http://dx.doi.org/10.3390/ijms23158179 |
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author | Tain, You-Lin Hsu, Chien-Ning |
author_facet | Tain, You-Lin Hsu, Chien-Ning |
author_sort | Tain, You-Lin |
collection | PubMed |
description | The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and associated diseases. Maternal diets rich in saturated fats have been widely employed in animal models to study various adverse offspring outcomes. In this review, we discussed current evidence linking maternal high-fat diet to offspring hypertension. We also provided an in-depth overview of the potential mechanisms underlying hypertension of developmental origins that are programmed by maternal high-fat intake from animal studies. Furthermore, this review also presented an overview of how reprogramming interventions can prevent maternal high-fat-diet-induced hypertension in adult offspring. Overall, recent advances in understanding mechanisms behind programming and reprogramming of maternal high-fat diet on hypertension of developmental origins might provide the answers to curtail this epidemic. Still, more research is needed to translate research findings into practice. |
format | Online Article Text |
id | pubmed-9332200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93322002022-07-29 Maternal High-Fat Diet and Offspring Hypertension Tain, You-Lin Hsu, Chien-Ning Int J Mol Sci Review The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and associated diseases. Maternal diets rich in saturated fats have been widely employed in animal models to study various adverse offspring outcomes. In this review, we discussed current evidence linking maternal high-fat diet to offspring hypertension. We also provided an in-depth overview of the potential mechanisms underlying hypertension of developmental origins that are programmed by maternal high-fat intake from animal studies. Furthermore, this review also presented an overview of how reprogramming interventions can prevent maternal high-fat-diet-induced hypertension in adult offspring. Overall, recent advances in understanding mechanisms behind programming and reprogramming of maternal high-fat diet on hypertension of developmental origins might provide the answers to curtail this epidemic. Still, more research is needed to translate research findings into practice. MDPI 2022-07-25 /pmc/articles/PMC9332200/ /pubmed/35897755 http://dx.doi.org/10.3390/ijms23158179 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tain, You-Lin Hsu, Chien-Ning Maternal High-Fat Diet and Offspring Hypertension |
title | Maternal High-Fat Diet and Offspring Hypertension |
title_full | Maternal High-Fat Diet and Offspring Hypertension |
title_fullStr | Maternal High-Fat Diet and Offspring Hypertension |
title_full_unstemmed | Maternal High-Fat Diet and Offspring Hypertension |
title_short | Maternal High-Fat Diet and Offspring Hypertension |
title_sort | maternal high-fat diet and offspring hypertension |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332200/ https://www.ncbi.nlm.nih.gov/pubmed/35897755 http://dx.doi.org/10.3390/ijms23158179 |
work_keys_str_mv | AT tainyoulin maternalhighfatdietandoffspringhypertension AT hsuchienning maternalhighfatdietandoffspringhypertension |