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Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review

The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. Howe...

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Detalles Bibliográficos
Autores principales: Li, Matu, Zheng, Ya, Zhao, Jinyu, Liu, Meimei, Shu, Xiaochuang, Li, Qiang, Wang, Yuping, Zhou, Yongning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332243/
https://www.ncbi.nlm.nih.gov/pubmed/35892986
http://dx.doi.org/10.3390/curroncol29080417
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author Li, Matu
Zheng, Ya
Zhao, Jinyu
Liu, Meimei
Shu, Xiaochuang
Li, Qiang
Wang, Yuping
Zhou, Yongning
author_facet Li, Matu
Zheng, Ya
Zhao, Jinyu
Liu, Meimei
Shu, Xiaochuang
Li, Qiang
Wang, Yuping
Zhou, Yongning
author_sort Li, Matu
collection PubMed
description The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC.
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spelling pubmed-93322432022-07-29 Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review Li, Matu Zheng, Ya Zhao, Jinyu Liu, Meimei Shu, Xiaochuang Li, Qiang Wang, Yuping Zhou, Yongning Curr Oncol Review The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC. MDPI 2022-07-25 /pmc/articles/PMC9332243/ /pubmed/35892986 http://dx.doi.org/10.3390/curroncol29080417 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Matu
Zheng, Ya
Zhao, Jinyu
Liu, Meimei
Shu, Xiaochuang
Li, Qiang
Wang, Yuping
Zhou, Yongning
Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
title Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
title_full Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
title_fullStr Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
title_full_unstemmed Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
title_short Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
title_sort polyphenol mechanisms against gastric cancer and their interactions with gut microbiota: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332243/
https://www.ncbi.nlm.nih.gov/pubmed/35892986
http://dx.doi.org/10.3390/curroncol29080417
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