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Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review
The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. Howe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332243/ https://www.ncbi.nlm.nih.gov/pubmed/35892986 http://dx.doi.org/10.3390/curroncol29080417 |
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author | Li, Matu Zheng, Ya Zhao, Jinyu Liu, Meimei Shu, Xiaochuang Li, Qiang Wang, Yuping Zhou, Yongning |
author_facet | Li, Matu Zheng, Ya Zhao, Jinyu Liu, Meimei Shu, Xiaochuang Li, Qiang Wang, Yuping Zhou, Yongning |
author_sort | Li, Matu |
collection | PubMed |
description | The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC. |
format | Online Article Text |
id | pubmed-9332243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93322432022-07-29 Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review Li, Matu Zheng, Ya Zhao, Jinyu Liu, Meimei Shu, Xiaochuang Li, Qiang Wang, Yuping Zhou, Yongning Curr Oncol Review The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC. MDPI 2022-07-25 /pmc/articles/PMC9332243/ /pubmed/35892986 http://dx.doi.org/10.3390/curroncol29080417 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Matu Zheng, Ya Zhao, Jinyu Liu, Meimei Shu, Xiaochuang Li, Qiang Wang, Yuping Zhou, Yongning Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review |
title | Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review |
title_full | Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review |
title_fullStr | Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review |
title_full_unstemmed | Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review |
title_short | Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review |
title_sort | polyphenol mechanisms against gastric cancer and their interactions with gut microbiota: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332243/ https://www.ncbi.nlm.nih.gov/pubmed/35892986 http://dx.doi.org/10.3390/curroncol29080417 |
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