The Role of PIM Kinases in Pediatric Solid Tumors

SIMPLE SUMMARY: PIM kinases are enzymes that have been identified as potential therapeutic targets in a number of cancers. In this review, we summarize the functions of PIM kinases and the roles they play in the development of cancer, with an emphasis on the discoveries of their functions in pediatr...

Descripción completa

Detalles Bibliográficos
Autores principales: Julson, Janet Rae, Marayati, Raoud, Beierle, Elizabeth Ann, Stafman, Laura Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332273/
https://www.ncbi.nlm.nih.gov/pubmed/35892829
http://dx.doi.org/10.3390/cancers14153565
Descripción
Sumario:SIMPLE SUMMARY: PIM kinases are enzymes that have been identified as potential therapeutic targets in a number of cancers. In this review, we summarize the functions of PIM kinases and the roles they play in the development of cancer, with an emphasis on the discoveries of their functions in pediatric malignancies. We also discuss the currently available drugs targeting PIM kinases and existing clinical trials. ABSTRACT: PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.

Ejemplares similares