Cargando…

Improved Therapeutic Efficacy of CBD with Good Tolerance in the Treatment of Breast Cancer through Nanoencapsulation and in Combination with 20(S)-Protopanaxadiol (PPD)

Cannabidiol (CBD), a nonpsychoactive major component derived from Cannabis sativa, widely used in neurodegenerative diseases, has now been proven to have growth inhibitory effects on many tumor cell lines, including breast tumors. Meanwhile CBD can effectively alleviate cancer-associated pain, anxie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Jingxin, Zhang, Kunfeng, Lu, Likang, Li, Manzhen, Han, Meihua, Guo, Yifei, Wang, Xiangtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332327/ https://www.ncbi.nlm.nih.gov/pubmed/35893789 http://dx.doi.org/10.3390/pharmaceutics14081533

Ejemplares similares

A γ-Glutamyl Transpeptidase (GGT)-Triggered Charge Reversal Drug-Delivery System for Cervical Cancer Treatment: In Vitro and In Vivo Investigation
por: Fu, Jingxin, et al.
Publicado: (2023)

Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over-threshold dosing
por: Ao, Hui, et al.
Publicado: (2022)

Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design
por: Kim, Min-Hwan, et al.
Publicado: (2019)

Effect of Ginseng Sapogenin Protopanaxadiol-Enriched Rice (DJ-PPD) on Immunomodulation
por: Monmai, Chaiwat, et al.
Publicado: (2023)

Enhanced Solubility and Antitumor Activity of Annona Squamosa Seed Oil via Nanoparticles Stabilized with TPGS: Preparation and In Vitro and In Vivo Evaluation
por: Ao, Hui, et al.
Publicado: (2022)

A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity
por: Wei, Shunfeng, et al.
Publicado: (2018)

A simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid
por: Fu, Jingxin, et al.
Publicado: (2022)

Mitochondrial-Targeted Triphenylphosphonium–Hydroxycamptothecin Conjugate and Its Nano-Formulations for Breast Cancer Therapy: In Vitro and In Vivo Investigation
por: Zhang, Kunfeng, et al.
Publicado: (2023)

Synergistic production of 20(S)-protopanaxadiol from protopanaxadiol-type ginsenosides by β-glycosidases from Dictyoglomus turgidum and Caldicellulosiruptor bescii
por: Choi, Ji-Hyeon, et al.
Publicado: (2017)

Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer
por: Wang, Yian, et al.
Publicado: (2020)

20(S)-Protopanaxadiol Inhibition of Progression and Growth of Castration-Resistant Prostate Cancer
por: Cao, Bo, et al.
Publicado: (2014)

20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration
por: LI, BIN, et al.
Publicado: (2016)

Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol
por: Zhang, Tiehua, et al.
Publicado: (2020)

Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions
por: Li, Haowen, et al.
Publicado: (2021)

Characterization, Molecular Docking, and In Vitro Dissolution Studies of Solid Dispersions of 20(S)-Protopanaxadiol
por: Zhang, Qi, et al.
Publicado: (2017)

The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginseng, according to fasting on hepatocellular carcinoma
por: Li, Wenzhen, et al.
Publicado: (2022)

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1
por: Wang, Yuchen, et al.
Publicado: (2019)

RAL PPD seminar
Publicado: (2016)

Beneficial effects of 20(S)-protopanaxadiol on antitumor activity and toxicity of cyclophosphamide in tumor-bearing mice
por: LIN, GUANGZHU, et al.
Publicado: (2013)

Polycaprolactone nanofibres loaded with 20(S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study
por: Liu, Dan-qing, et al.
Publicado: (2018)

Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio)
por: Grasse, Nico, et al.
Publicado: (2023)

Neuroprotective effects of 20(S)-protopanaxadiol against glutamate-induced mitochondrial dysfunction in PC12 cells
por: BAK, DONG-HO, et al.
Publicado: (2016)

20(S)-Protopanaxadiol Phospholipid Complex: Process Optimization, Characterization, In Vitro Dissolution and Molecular Docking Studies
por: Pu, Yiqiong, et al.
Publicado: (2016)

Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis
por: Jo, Hantae, et al.
Publicado: (2021)

Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways
por: Ren, Guoqing, et al.
Publicado: (2023)

Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction
por: Chen, Feiyan, et al.
Publicado: (2023)

20-O-β-d-Xylopyranosyl(1→6)-β-d-glucopyranosyl-20(S)-protopanaxadiol methanol solvate
por: Li, Xing-Wei, et al.
Publicado: (2007)

Nanoencapsulation for drug delivery
por: Kumari, Avnesh, et al.
Publicado: (2014)

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
por: Li, Haowen, et al.
Publicado: (2020)

20(S)‐Protopanaxadiol inhibits epithelial‐mesenchymal transition by promoting retinoid X receptor alpha in human colorectal carcinoma cells
por: Lu, Zeyuan, et al.
Publicado: (2020)

Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways
por: GAO, JIAN-LI, et al.
Publicado: (2013)

20(S)-protopanaxadiol regio-selectively targets androgen receptor: anticancer effects in castration-resistant prostate tumors
por: Ben-Eltriki, Mohamed, et al.
Publicado: (2018)

Platelet Protease Activated Receptor 1 Is Involved in the Hemostatic Effect of 20(S)-Protopanaxadiol by Regulating Calcium Signaling
por: Zhang, He, et al.
Publicado: (2020)

Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis
por: Guo, Wenna, et al.
Publicado: (2020)

Efficient strategies for controlled release of nanoencapsulated phytohormones to improve plant stress tolerance
por: Sampedro-Guerrero, Jimmy, et al.
Publicado: (2023)

Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders
por: Baswan, Sudhir M, et al.
Publicado: (2020)

The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation
por: Kang, Soouk, et al.
Publicado: (2014)

Study on the hypnotic effect of rare protopanaxadiol-type and protopanaxatriol-type ginsenosides
por: Mou, Ning, et al.
Publicado: (2019)

Stereoselective Property of 20(S)-Protopanaxadiol Ocotillol Type Epimers Affects Its Absorption and Also the Inhibition of P-Glycoprotein
por: Wang, Wenyan, et al.
Publicado: (2014)

Development of 20(S)-Protopanaxadiol-Loaded SNEDDS Preconcentrate Using Comprehensive Phase Diagram for the Enhanced Dissolution and Oral Bioavailability
por: Kim, Young Hoon, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jp5fvpq1lfdfj60u3e4ispelmg