Cargando…

Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan

Inflammatory responses contribute to physical decline in older adults. Clinical studies have shown that the neutrophil-to-lymphocyte ratio (NLR), a marker of inflammation, is associated with physical decline. However, its association with physical function in community-dwelling older people is still...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshida, Yuko, Iwasa, Hajime, Kim, Hunkyung, Suzuki, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332416/
https://www.ncbi.nlm.nih.gov/pubmed/35897367
http://dx.doi.org/10.3390/ijerph19158996
_version_ 1784758641453170688
author Yoshida, Yuko
Iwasa, Hajime
Kim, Hunkyung
Suzuki, Takao
author_facet Yoshida, Yuko
Iwasa, Hajime
Kim, Hunkyung
Suzuki, Takao
author_sort Yoshida, Yuko
collection PubMed
description Inflammatory responses contribute to physical decline in older adults. Clinical studies have shown that the neutrophil-to-lymphocyte ratio (NLR), a marker of inflammation, is associated with physical decline. However, its association with physical function in community-dwelling older people is still unclear. Hence, we used cross-sectional data to investigate the relationship between NLR and physical function in community-dwelling older adults. Specifically, we analyzed data corresponding to 818 individuals (336 men and 482 women) aged ≥ 75 years, all of whom participated in comprehensive health examinations, including face-to-face interviews, biochemical analyses, and physical function tests. Using these data, we performed multivariable logistic regression analysis to assess the relationship between NLR and physical function, adjusting for sex, age, education, alcohol consumption, smoking, instrumental activity of daily living, body mass index, chronic disease, physical activity, serum albumin level, and depressive mood. The results showed that a higher NLR was associated with a lower grip strength, lower knee extension strength, and slower walking speed. Importantly, the relationship between NLR and physical function was maintained after adjusting for the confounding factors. Thus, we showed a significant association between NLR and physical function, supporting the use of NLR as a marker of physical function in community-dwelling older adults.
format Online
Article
Text
id pubmed-9332416
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93324162022-07-29 Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan Yoshida, Yuko Iwasa, Hajime Kim, Hunkyung Suzuki, Takao Int J Environ Res Public Health Article Inflammatory responses contribute to physical decline in older adults. Clinical studies have shown that the neutrophil-to-lymphocyte ratio (NLR), a marker of inflammation, is associated with physical decline. However, its association with physical function in community-dwelling older people is still unclear. Hence, we used cross-sectional data to investigate the relationship between NLR and physical function in community-dwelling older adults. Specifically, we analyzed data corresponding to 818 individuals (336 men and 482 women) aged ≥ 75 years, all of whom participated in comprehensive health examinations, including face-to-face interviews, biochemical analyses, and physical function tests. Using these data, we performed multivariable logistic regression analysis to assess the relationship between NLR and physical function, adjusting for sex, age, education, alcohol consumption, smoking, instrumental activity of daily living, body mass index, chronic disease, physical activity, serum albumin level, and depressive mood. The results showed that a higher NLR was associated with a lower grip strength, lower knee extension strength, and slower walking speed. Importantly, the relationship between NLR and physical function was maintained after adjusting for the confounding factors. Thus, we showed a significant association between NLR and physical function, supporting the use of NLR as a marker of physical function in community-dwelling older adults. MDPI 2022-07-24 /pmc/articles/PMC9332416/ /pubmed/35897367 http://dx.doi.org/10.3390/ijerph19158996 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshida, Yuko
Iwasa, Hajime
Kim, Hunkyung
Suzuki, Takao
Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan
title Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan
title_full Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan
title_fullStr Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan
title_full_unstemmed Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan
title_short Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan
title_sort association between neutrophil-to-lymphocyte ratio and physical function in older adults: a community-based cross-sectional study in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332416/
https://www.ncbi.nlm.nih.gov/pubmed/35897367
http://dx.doi.org/10.3390/ijerph19158996
work_keys_str_mv AT yoshidayuko associationbetweenneutrophiltolymphocyteratioandphysicalfunctioninolderadultsacommunitybasedcrosssectionalstudyinjapan
AT iwasahajime associationbetweenneutrophiltolymphocyteratioandphysicalfunctioninolderadultsacommunitybasedcrosssectionalstudyinjapan
AT kimhunkyung associationbetweenneutrophiltolymphocyteratioandphysicalfunctioninolderadultsacommunitybasedcrosssectionalstudyinjapan
AT suzukitakao associationbetweenneutrophiltolymphocyteratioandphysicalfunctioninolderadultsacommunitybasedcrosssectionalstudyinjapan