Cargando…
A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation
Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases,small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blo...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taiwan Food and Drug Administration
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332536/ https://www.ncbi.nlm.nih.gov/pubmed/28911684 http://dx.doi.org/10.1016/j.jfda.2016.06.011 |
_version_ | 1784758671932129280 |
---|---|
author | Wang, Yin-Ruei Liu, Sheng-Fu Shen, You-Cheng Chen, Chien-Li Huang, Chine-Ning Pan, Tzu-Ming Wang, Chin-Kun |
author_facet | Wang, Yin-Ruei Liu, Sheng-Fu Shen, You-Cheng Chen, Chien-Li Huang, Chine-Ning Pan, Tzu-Ming Wang, Chin-Kun |
author_sort | Wang, Yin-Ruei |
collection | PubMed |
description | Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases,small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blood lipids. This study enrolled 39 patients with a fasting blood glucose level between 100 mg/dL and 180 mg/dL, and a glycated hemoglobin (HbA1c) level of <9%. All patients were randomly divided into placebo (n = 20) and experimental (n = 19) groups. Each patient received two placebo capsules (maltodextrin) or ANKASCIN 568 plus capsules daily for 12 weeks. The patients were screened during follow-up 4 weeks after the administration of sample or placebo had been discontinued. Blood and urine samples were collected at the initial, 6(th) week, 12(th) week, and 16(th) week. The anthropometric indicators of blood pressure, fasting plasma glucose level, postprandial plasma glucose level, insulin level, insulin resistance, blood lipid changes, and liver, kidney, and thyroid function indices were measured. After 6weeks, changes in fasting blood glucose, low-density lipoprotein cholesterol (LDL-C),and total cholesterol (TC) levels showed thatANKASCIN568 plus had amore favorable effect than the placebo. Compared to baseline, a statistically significant decrease of 8.5%, 10.3%, and 7.5% was observed in fasting blood glucose, LDL-C and, TC levels, respectively (p < 0.05 for all pairs). Therefore, ANKASCIN568 plus produced by Monascus purpureus NTU 568 fermentation may be a potentially useful agent for the regulation of blood glucose and blood lipids and for treatment of coronary artery diseases. |
format | Online Article Text |
id | pubmed-9332536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taiwan Food and Drug Administration |
record_format | MEDLINE/PubMed |
spelling | pubmed-93325362022-08-09 A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation Wang, Yin-Ruei Liu, Sheng-Fu Shen, You-Cheng Chen, Chien-Li Huang, Chine-Ning Pan, Tzu-Ming Wang, Chin-Kun J Food Drug Anal Original Article Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases,small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blood lipids. This study enrolled 39 patients with a fasting blood glucose level between 100 mg/dL and 180 mg/dL, and a glycated hemoglobin (HbA1c) level of <9%. All patients were randomly divided into placebo (n = 20) and experimental (n = 19) groups. Each patient received two placebo capsules (maltodextrin) or ANKASCIN 568 plus capsules daily for 12 weeks. The patients were screened during follow-up 4 weeks after the administration of sample or placebo had been discontinued. Blood and urine samples were collected at the initial, 6(th) week, 12(th) week, and 16(th) week. The anthropometric indicators of blood pressure, fasting plasma glucose level, postprandial plasma glucose level, insulin level, insulin resistance, blood lipid changes, and liver, kidney, and thyroid function indices were measured. After 6weeks, changes in fasting blood glucose, low-density lipoprotein cholesterol (LDL-C),and total cholesterol (TC) levels showed thatANKASCIN568 plus had amore favorable effect than the placebo. Compared to baseline, a statistically significant decrease of 8.5%, 10.3%, and 7.5% was observed in fasting blood glucose, LDL-C and, TC levels, respectively (p < 0.05 for all pairs). Therefore, ANKASCIN568 plus produced by Monascus purpureus NTU 568 fermentation may be a potentially useful agent for the regulation of blood glucose and blood lipids and for treatment of coronary artery diseases. Taiwan Food and Drug Administration 2016-07-30 /pmc/articles/PMC9332536/ /pubmed/28911684 http://dx.doi.org/10.1016/j.jfda.2016.06.011 Text en © 2017 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Original Article Wang, Yin-Ruei Liu, Sheng-Fu Shen, You-Cheng Chen, Chien-Li Huang, Chine-Ning Pan, Tzu-Ming Wang, Chin-Kun A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation |
title | A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation |
title_full | A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation |
title_fullStr | A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation |
title_full_unstemmed | A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation |
title_short | A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation |
title_sort | randomized, double-blind clinical study to determine the effect of ankascin 568 plus on blood glucose regulation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332536/ https://www.ncbi.nlm.nih.gov/pubmed/28911684 http://dx.doi.org/10.1016/j.jfda.2016.06.011 |
work_keys_str_mv | AT wangyinruei arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT liushengfu arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT shenyoucheng arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT chenchienli arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT huangchinening arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT pantzuming arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT wangchinkun arandomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT wangyinruei randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT liushengfu randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT shenyoucheng randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT chenchienli randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT huangchinening randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT pantzuming randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation AT wangchinkun randomizeddoubleblindclinicalstudytodeterminetheeffectofankascin568plusonbloodglucoseregulation |