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Metabolite profiling, antioxidant, and α-glucosidase inhibitory activities of germinated rice: nuclear-magnetic-resonance-based metabolomics study

In an attempt to profile the metabolites of three different varieties of germinated rice, specifically black (GBR), red, and white rice, a (1)H-nuclear-magnetic-resonance-based metabolomics approach was conducted. Multivariate data analysis was applied to discriminate between the three different var...

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Detalles Bibliográficos
Autores principales: Pramai, Phaiwan, Hamid, Nur Ashikin Abdul, Mediani, Ahmed, Maulidiani, Maulidiani, Abas, Faridah, Jiamyangyuen, Sudarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332653/
https://www.ncbi.nlm.nih.gov/pubmed/29389588
http://dx.doi.org/10.1016/j.jfda.2016.11.023
Descripción
Sumario:In an attempt to profile the metabolites of three different varieties of germinated rice, specifically black (GBR), red, and white rice, a (1)H-nuclear-magnetic-resonance-based metabolomics approach was conducted. Multivariate data analysis was applied to discriminate between the three different varieties using a partial least squares discriminant analysis (PLS-DA) model. The PLS model was used to evaluate the relationship between chemicals and biological activities of germinated rice. The PLS-DA score plot exhibited a noticeable separation between the three rice varieties into three clusters by PC1 and PC2. The PLS model indicated that α-linolenic acid, γ-oryzanol, α-tocopherol, γ-aminobutyric acid, 3-hydroxybutyric acid, fumaric acid, fatty acids, threonine, tryptophan, and vanillic acid were significantly correlated with the higher bioactivities demonstrated by GBR that was extracted in 100% ethanol. Subsequently, the proposed biosynthetic pathway analysis revealed that the increased quantities of secondary metabolites found in GBR may contribute to its nutritional value and health benefits.