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Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial

Pearl is one of the well-known traditional Chinese medicine (TCM) prescribed for treating various skin and bone related disorders due to its abundant proteins and mineral contents. The present investigation focused on antioxidation and life span prolonging effects from different extracts of pearl po...

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Autores principales: Chiu, Hui-Fang, Hsiao, Su-Chun, Lu, Yan-Ying, Han, Yi-Chun, Shen, You-Cheng, Venkatakrishnan, Kamesh, Wang, Chin-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332669/
https://www.ncbi.nlm.nih.gov/pubmed/29389568
http://dx.doi.org/10.1016/j.jfda.2017.05.010
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author Chiu, Hui-Fang
Hsiao, Su-Chun
Lu, Yan-Ying
Han, Yi-Chun
Shen, You-Cheng
Venkatakrishnan, Kamesh
Wang, Chin-Kun
author_facet Chiu, Hui-Fang
Hsiao, Su-Chun
Lu, Yan-Ying
Han, Yi-Chun
Shen, You-Cheng
Venkatakrishnan, Kamesh
Wang, Chin-Kun
author_sort Chiu, Hui-Fang
collection PubMed
description Pearl is one of the well-known traditional Chinese medicine (TCM) prescribed for treating various skin and bone related disorders due to its abundant proteins and mineral contents. The present investigation focused on antioxidation and life span prolonging effects from different extracts of pearl powder. During in vitro studies, various oxidative indices were evaluated, along with lifespan-prolonging effect were checked using wild-type Caenorhabditis elegans. For the clinical trial, 20 healthy middle-aged subjects were recruited and separated into 2 groups as experimental and placebo group, who received 3 g of pearl powder/d (n = 10) and 3 g of placebo/d (n = 10) for 8 weeks, respectively. During the initial, 2nd, 4th, 6th, 8th and 10th weeks the blood samples were collected for biochemical analysis. The protein extract of pearl powder recorded maximum (p < 0.05) antioxidant activity (20–68%) as well as efficiently prolonged the life span of C. elegans by 18.87%. Pearl powder supplemented subjects showed a substantial increase (p < 0.05) in total antioxidant capacity from 0.45 to 0.69 mM, total thiols from 0.23 to 0.29 mM, Glutathione content from 5.89 to 9.19 μM, enzymic antioxidant activity (SOD-1248 to 1308; Gpx-30 to 32; GR-2.4 to 2.9) as well as considerably suppressed the lipid peroxidation products from 4.95 to 3.27 μM. The outcome of both in-vitro and in-vivo antioxidant activity inferred that protein extract of pearl powder was a potent antioxidant and thereby prolonged the lifespan of C. elegans. Hence, pearl powder could be recommended for treating various age-related degenerative disorders.
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spelling pubmed-93326692022-08-09 Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial Chiu, Hui-Fang Hsiao, Su-Chun Lu, Yan-Ying Han, Yi-Chun Shen, You-Cheng Venkatakrishnan, Kamesh Wang, Chin-Kun J Food Drug Anal Original Article Pearl is one of the well-known traditional Chinese medicine (TCM) prescribed for treating various skin and bone related disorders due to its abundant proteins and mineral contents. The present investigation focused on antioxidation and life span prolonging effects from different extracts of pearl powder. During in vitro studies, various oxidative indices were evaluated, along with lifespan-prolonging effect were checked using wild-type Caenorhabditis elegans. For the clinical trial, 20 healthy middle-aged subjects were recruited and separated into 2 groups as experimental and placebo group, who received 3 g of pearl powder/d (n = 10) and 3 g of placebo/d (n = 10) for 8 weeks, respectively. During the initial, 2nd, 4th, 6th, 8th and 10th weeks the blood samples were collected for biochemical analysis. The protein extract of pearl powder recorded maximum (p < 0.05) antioxidant activity (20–68%) as well as efficiently prolonged the life span of C. elegans by 18.87%. Pearl powder supplemented subjects showed a substantial increase (p < 0.05) in total antioxidant capacity from 0.45 to 0.69 mM, total thiols from 0.23 to 0.29 mM, Glutathione content from 5.89 to 9.19 μM, enzymic antioxidant activity (SOD-1248 to 1308; Gpx-30 to 32; GR-2.4 to 2.9) as well as considerably suppressed the lipid peroxidation products from 4.95 to 3.27 μM. The outcome of both in-vitro and in-vivo antioxidant activity inferred that protein extract of pearl powder was a potent antioxidant and thereby prolonged the lifespan of C. elegans. Hence, pearl powder could be recommended for treating various age-related degenerative disorders. Taiwan Food and Drug Administration 2017-06-13 /pmc/articles/PMC9332669/ /pubmed/29389568 http://dx.doi.org/10.1016/j.jfda.2017.05.010 Text en © 2018 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Chiu, Hui-Fang
Hsiao, Su-Chun
Lu, Yan-Ying
Han, Yi-Chun
Shen, You-Cheng
Venkatakrishnan, Kamesh
Wang, Chin-Kun
Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
title Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
title_full Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
title_fullStr Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
title_full_unstemmed Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
title_short Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
title_sort efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332669/
https://www.ncbi.nlm.nih.gov/pubmed/29389568
http://dx.doi.org/10.1016/j.jfda.2017.05.010
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