Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands

A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety in a lead compound with diazaspiroalkanes and the fused octahydropyrrolo[3,4-b] pyrrole ring system resulted in a loss in affin...

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Detalles Bibliográficos
Autores principales: Xu, Kuiying, Hsieh, Chia-Ju, Lee, Ji Youn, Riad, Aladdin, Izzo, Nicholas J., Look, Gary, Catalano, Susan, Mach, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332756/
https://www.ncbi.nlm.nih.gov/pubmed/35897835
http://dx.doi.org/10.3390/ijms23158259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332756/
https://www.ncbi.nlm.nih.gov/pubmed/35897835
http://dx.doi.org/10.3390/ijms23158259

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