Spotted Fever Group Rickettsioses in Central America: The Research and Public Health Disparity among Socioeconomic Lines

SIMPLE SUMMARY: Tick-borne diseases are an important public health issue globally. Spotted fever group rickettsioses (SFGR), a group of related tick-borne pathogens, can cause significant disease, but is widely underreported and likely misdiagnosed. In Central America, there is little known about SFGR, and there seems to be a socioeconomic-related difference between the most-developed and least-developed countries in the region. The least-developed countries (El Salvador, Guatemala, Honduras, and Nicaragua) disproportionately underreport research or studies regarding SFGR disease compared to the most-developed countries (Belize, Panama, and Costa Rica). We compared human development and poverty indicators among Central American countries for this review of SFGR Rickettsia-related articles. The least-developed countries are at a higher risk or are more vulnerable to SFGR disease than the most-developed countries in this region. ABSTRACT: Tick-borne diseases including rickettsial diseases are increasing in incidence worldwide. Many rickettsial pathogens can cause disease which is commonly underdiagnosed and underreported; Rickettsia pathogens in the spotted fever group (SFGR) are thus classified as neglected bacterial pathogens. The Central American region shoulders a large proportion of the global neglected disease burden; however, little is known regarding SFGR disease here. Although development varies, four of the seven countries in this region have both the highest poverty rates and SFGR disease burdens (El Salvador, Honduras, Guatemala, and Nicaragua), compared to Belize, Panama, and Costa Rica. Utilizing the Human Development Index (HDI), we compared published articles related to SFGR Rickettsia prevalence in the lowest-HDI-scoring countries to the highest-HDI-scoring countries. Our analysis identified a distinct dichotomy in publication, and by proxy, potentially awareness and knowledge of SFGR tick-borne disease in Central America, where the least-developed countries are at the highest risk for, yet the most vulnerable to, SFGR disease.