Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins

Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to protein modification under visible light exposure are not understood. Potentially, these processes may be triggered by a ligand to metal charge t...

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Detalles Bibliográficos
Autor principal: Schöneich, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332834/
https://www.ncbi.nlm.nih.gov/pubmed/35897838
http://dx.doi.org/10.3390/ijms23158262
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author Schöneich, Christian
author_facet Schöneich, Christian
author_sort Schöneich, Christian
collection PubMed
description Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to protein modification under visible light exposure are not understood. Potentially, these processes may be triggered by a ligand to metal charge transfer in excipient-metal complexes. This article summarizes recent analytical and mechanistic work on such reactions under experimental conditions relevant to pharmaceutical formulations.
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spelling pubmed-93328342022-07-29 Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins Schöneich, Christian Int J Mol Sci Review Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to protein modification under visible light exposure are not understood. Potentially, these processes may be triggered by a ligand to metal charge transfer in excipient-metal complexes. This article summarizes recent analytical and mechanistic work on such reactions under experimental conditions relevant to pharmaceutical formulations. MDPI 2022-07-27 /pmc/articles/PMC9332834/ /pubmed/35897838 http://dx.doi.org/10.3390/ijms23158262 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schöneich, Christian
Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins
title Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins
title_full Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins
title_fullStr Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins
title_full_unstemmed Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins
title_short Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins
title_sort advanced oxidation processes in pharmaceutical formulations: photo-fenton degradation of peptides and proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332834/
https://www.ncbi.nlm.nih.gov/pubmed/35897838
http://dx.doi.org/10.3390/ijms23158262
work_keys_str_mv AT schoneichchristian advancedoxidationprocessesinpharmaceuticalformulationsphotofentondegradationofpeptidesandproteins

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