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New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study

Background: In recent decades, hyaluronic acid (HA) has attracted great attention as a new treatment option for osteoarthritis. Classical therapies are not able to stop the cartilage degeneration process nor do they favor tissue repair. Nowadays, it is accepted that high molecular weight HA can redu...

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Autores principales: Galla, Rebecca, Ruga, Sara, Aprile, Silvio, Ferrari, Sara, Brovero, Arianna, Grosa, Giorgio, Molinari, Claudio, Uberti, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332867/
https://www.ncbi.nlm.nih.gov/pubmed/35897688
http://dx.doi.org/10.3390/ijms23158114
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author Galla, Rebecca
Ruga, Sara
Aprile, Silvio
Ferrari, Sara
Brovero, Arianna
Grosa, Giorgio
Molinari, Claudio
Uberti, Francesca
author_facet Galla, Rebecca
Ruga, Sara
Aprile, Silvio
Ferrari, Sara
Brovero, Arianna
Grosa, Giorgio
Molinari, Claudio
Uberti, Francesca
author_sort Galla, Rebecca
collection PubMed
description Background: In recent decades, hyaluronic acid (HA) has attracted great attention as a new treatment option for osteoarthritis. Classical therapies are not able to stop the cartilage degeneration process nor do they favor tissue repair. Nowadays, it is accepted that high molecular weight HA can reduce inflammation by promoting tissue regeneration; therefore, the aim of this study was to verify the efficacy of a new high molecular weight HA of plant origin (called GreenIuronic(®)) in maintaining joint homeostasis and preventing the harmful processes of osteoarthritis. Methods: The bioavailability of GreenIuronic(®) was investigated in a 3D intestinal barrier model that mimics human oral intake while excluding damage to the intestinal barrier. Furthermore, the chemical significance and biological properties of GreenIuronic(®) were investigated in conditions that simulate osteoarthritis. Results: Our data demonstrated that GreenIuronic(®) crosses the intestinal barrier without side effects as it has a chemical–biological profile, which could be responsible for many specific chondrocyte functions. Furthermore, in the osteoarthritis model, GreenIuronic(®) can modulate the molecular mechanism responsible for preventing and restoring the degradation of cartilage. Conclusion: According to our results, this new form of HA appears to be well absorbed and distributed to chondrocytes, preserving their biological activities. Therefore, the oral administration of GreenIuronic(®) in humans can be considered a valid strategy to obtain beneficial therapeutic effects during osteoarthritis.
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spelling pubmed-93328672022-07-29 New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study Galla, Rebecca Ruga, Sara Aprile, Silvio Ferrari, Sara Brovero, Arianna Grosa, Giorgio Molinari, Claudio Uberti, Francesca Int J Mol Sci Article Background: In recent decades, hyaluronic acid (HA) has attracted great attention as a new treatment option for osteoarthritis. Classical therapies are not able to stop the cartilage degeneration process nor do they favor tissue repair. Nowadays, it is accepted that high molecular weight HA can reduce inflammation by promoting tissue regeneration; therefore, the aim of this study was to verify the efficacy of a new high molecular weight HA of plant origin (called GreenIuronic(®)) in maintaining joint homeostasis and preventing the harmful processes of osteoarthritis. Methods: The bioavailability of GreenIuronic(®) was investigated in a 3D intestinal barrier model that mimics human oral intake while excluding damage to the intestinal barrier. Furthermore, the chemical significance and biological properties of GreenIuronic(®) were investigated in conditions that simulate osteoarthritis. Results: Our data demonstrated that GreenIuronic(®) crosses the intestinal barrier without side effects as it has a chemical–biological profile, which could be responsible for many specific chondrocyte functions. Furthermore, in the osteoarthritis model, GreenIuronic(®) can modulate the molecular mechanism responsible for preventing and restoring the degradation of cartilage. Conclusion: According to our results, this new form of HA appears to be well absorbed and distributed to chondrocytes, preserving their biological activities. Therefore, the oral administration of GreenIuronic(®) in humans can be considered a valid strategy to obtain beneficial therapeutic effects during osteoarthritis. MDPI 2022-07-23 /pmc/articles/PMC9332867/ /pubmed/35897688 http://dx.doi.org/10.3390/ijms23158114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Galla, Rebecca
Ruga, Sara
Aprile, Silvio
Ferrari, Sara
Brovero, Arianna
Grosa, Giorgio
Molinari, Claudio
Uberti, Francesca
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study
title New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study
title_full New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study
title_fullStr New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study
title_full_unstemmed New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study
title_short New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study
title_sort new hyaluronic acid from plant origin to improve joint protection—an in vitro study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332867/
https://www.ncbi.nlm.nih.gov/pubmed/35897688
http://dx.doi.org/10.3390/ijms23158114
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