Cargando…

Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels

PURPOSE: To evaluate corneal densitometry (CD) of patients with arcus senilis (AS) and its association with the serum lipid markers. METHODS: This is a cross-sectional, case-control study. The AS diagnosis was made clinically. Forty-five eyes of 45 patients with AS and 38 eyes of 38 age-matched cont...

Descripción completa

Detalles Bibliográficos
Autores principales: Yilmaz, Yusuf Cem, Ipek, Sefik Can, Ozer, Muhammet Derda, Celebi, Tugba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332968/
https://www.ncbi.nlm.nih.gov/pubmed/35502026
http://dx.doi.org/10.4103/ijo.IJO_2696_21
_version_ 1784758776816992256
author Yilmaz, Yusuf Cem
Ipek, Sefik Can
Ozer, Muhammet Derda
Celebi, Tugba
author_facet Yilmaz, Yusuf Cem
Ipek, Sefik Can
Ozer, Muhammet Derda
Celebi, Tugba
author_sort Yilmaz, Yusuf Cem
collection PubMed
description PURPOSE: To evaluate corneal densitometry (CD) of patients with arcus senilis (AS) and its association with the serum lipid markers. METHODS: This is a cross-sectional, case-control study. The AS diagnosis was made clinically. Forty-five eyes of 45 patients with AS and 38 eyes of 38 age-matched control subjects with no noticeable AS were enrolled in the study. All participants underwent detailed ophthalmologic examination along with corneal Scheimpflug imaging with CD measurement. The evaluated serum lipid markers of the participants included total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL). The Spearman correlation analysis was used to correlate the serum lipid values and the CD. P < 0.05 was defined as statistically significant. RESULTS: The male to female ratio was 26/19 and 14/24 in the study and control groups, respectively (P = 0.057). The mean age was 59.56 ± 8.7 and 56.47 ± 8.6 years in the study and control groups, respectively (P = 0.117). The mean total CD values in the zones extending from 2 to 12 mm were higher in the study group than in the control group (P < 0.001). The serum HDL level was found to be significantly decreased in the study group compared to the control group (P = 0.048 and Z = −1.976). There was a significant positive correlation between the serum triglyceride level and the CD value of the outermost zone (10–12 mm) (r = 0.334 and P = 0.025). CONCLUSION: The CD of patients with AS was found to increase not only in the peripheral zone but also in the cornea’s paracentral zone compared to the healthy controls. The serum triglyceride level should give an insight into the intensity of arcus senilis. The serum HDL levels were decreased in patients with AS.
format Online
Article
Text
id pubmed-9332968
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-93329682022-07-29 Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels Yilmaz, Yusuf Cem Ipek, Sefik Can Ozer, Muhammet Derda Celebi, Tugba Indian J Ophthalmol Original Article PURPOSE: To evaluate corneal densitometry (CD) of patients with arcus senilis (AS) and its association with the serum lipid markers. METHODS: This is a cross-sectional, case-control study. The AS diagnosis was made clinically. Forty-five eyes of 45 patients with AS and 38 eyes of 38 age-matched control subjects with no noticeable AS were enrolled in the study. All participants underwent detailed ophthalmologic examination along with corneal Scheimpflug imaging with CD measurement. The evaluated serum lipid markers of the participants included total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL). The Spearman correlation analysis was used to correlate the serum lipid values and the CD. P < 0.05 was defined as statistically significant. RESULTS: The male to female ratio was 26/19 and 14/24 in the study and control groups, respectively (P = 0.057). The mean age was 59.56 ± 8.7 and 56.47 ± 8.6 years in the study and control groups, respectively (P = 0.117). The mean total CD values in the zones extending from 2 to 12 mm were higher in the study group than in the control group (P < 0.001). The serum HDL level was found to be significantly decreased in the study group compared to the control group (P = 0.048 and Z = −1.976). There was a significant positive correlation between the serum triglyceride level and the CD value of the outermost zone (10–12 mm) (r = 0.334 and P = 0.025). CONCLUSION: The CD of patients with AS was found to increase not only in the peripheral zone but also in the cornea’s paracentral zone compared to the healthy controls. The serum triglyceride level should give an insight into the intensity of arcus senilis. The serum HDL levels were decreased in patients with AS. Wolters Kluwer - Medknow 2022-05 2022-04-28 /pmc/articles/PMC9332968/ /pubmed/35502026 http://dx.doi.org/10.4103/ijo.IJO_2696_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Yilmaz, Yusuf Cem
Ipek, Sefik Can
Ozer, Muhammet Derda
Celebi, Tugba
Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
title Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
title_full Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
title_fullStr Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
title_full_unstemmed Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
title_short Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
title_sort corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332968/
https://www.ncbi.nlm.nih.gov/pubmed/35502026
http://dx.doi.org/10.4103/ijo.IJO_2696_21
work_keys_str_mv AT yilmazyusufcem cornealdensitometryinpatientswitharcussenilisanditscorrelationwithserumlipidlevels
AT ipeksefikcan cornealdensitometryinpatientswitharcussenilisanditscorrelationwithserumlipidlevels
AT ozermuhammetderda cornealdensitometryinpatientswitharcussenilisanditscorrelationwithserumlipidlevels
AT celebitugba cornealdensitometryinpatientswitharcussenilisanditscorrelationwithserumlipidlevels