Selective targeting BMP2 and 4 in SMAD4 negative esophageal adenocarcinoma inhibits tumor growth and aggressiveness in preclinical models

PURPOSE: Abnormalities within the Sonic Hedgehog (SHH), Bone Morphogenetic Protein (BMP) and SMAD4 signalling pathways have been associated with the malignant behavior of esophageal adenocarcinoma (EAC). We recently developed two specific llama-derived antibodies (VHHs), C4C4 and C8C8, which target...

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Detalles Bibliográficos
Autores principales: Li, Shulin, Hoefnagel, Sanne J. M., Read, Matthew, Meijer, Sybren, van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Bonora, Elena, Liu, David S. H., Phillips, Wayne A., Calpe, Silvia, Correia, Ana C. P., Sancho-Serra, Maria D. C., Mattioli, Sandro, Krishnadath, Kausilia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333053/
https://www.ncbi.nlm.nih.gov/pubmed/35902550
http://dx.doi.org/10.1007/s13402-022-00689-2

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