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Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study

BACKGROUND: Previous studies have suggested a close link between sleep disturbances and diabetic retinopathy (DR). However, to date, no confirmatory findings have been reported. We aimed to explore the risk of insomnia in DR by considering demographic factors and diabetes mellitus (DM)-related varia...

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Autores principales: Um, Yoo Hyun, Kim, Tae-Won, Jeong, Jong-Hyun, Hong, Seung-Chul, Seo, Ho-Jun, Han, Kyung-Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333090/
https://www.ncbi.nlm.nih.gov/pubmed/35909567
http://dx.doi.org/10.3389/fendo.2022.939251
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author Um, Yoo Hyun
Kim, Tae-Won
Jeong, Jong-Hyun
Hong, Seung-Chul
Seo, Ho-Jun
Han, Kyung-Do
author_facet Um, Yoo Hyun
Kim, Tae-Won
Jeong, Jong-Hyun
Hong, Seung-Chul
Seo, Ho-Jun
Han, Kyung-Do
author_sort Um, Yoo Hyun
collection PubMed
description BACKGROUND: Previous studies have suggested a close link between sleep disturbances and diabetic retinopathy (DR). However, to date, no confirmatory findings have been reported. We aimed to explore the risk of insomnia in DR by considering demographic factors and diabetes mellitus (DM)-related variables. METHODS: A nationwide population-based cohort of 2,206,619 patients with type 2 diabetes from the Korean National Insurance Service Database was followed up for insomnia incidence. DR, non-proliferative DR (NPDR), and proliferative DR (PDR) were defined according to ICD-10 codes. The interactive effects of sex, age, and DM-related variables were analyzed to evaluate their impact on insomnia risk in DR. RESULTS: Compared with the non-DR group, insomnia risk was increased in the DR [(adjusted hazard ratio (aHR): 1.125, 95% confidence interval (CI):1.108-1.142), NPDR (aHR:1.117, 95% CI:1.099-1.134), and PDR (aHR:1.205, 95% CI: 1.156-1.256), even after controlling for comorbidities, lifestyle factors, and DM-related variables. The men and youngest age groups (<40 years) were most vulnerable to insomnia risk. Sex, age, DM duration, and chronic kidney disease (CKD) status exerted interactive effects with DR status in increasing the insomnia risk. In the PDR group, sex, age, DM duration, insulin therapy status, and CKD status exerted interactive effects that increased the risk of insomnia. CONCLUSION: Insomnia risk is significantly higher in patients with DR, and clinical attention is warranted.
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spelling pubmed-93330902022-07-29 Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study Um, Yoo Hyun Kim, Tae-Won Jeong, Jong-Hyun Hong, Seung-Chul Seo, Ho-Jun Han, Kyung-Do Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Previous studies have suggested a close link between sleep disturbances and diabetic retinopathy (DR). However, to date, no confirmatory findings have been reported. We aimed to explore the risk of insomnia in DR by considering demographic factors and diabetes mellitus (DM)-related variables. METHODS: A nationwide population-based cohort of 2,206,619 patients with type 2 diabetes from the Korean National Insurance Service Database was followed up for insomnia incidence. DR, non-proliferative DR (NPDR), and proliferative DR (PDR) were defined according to ICD-10 codes. The interactive effects of sex, age, and DM-related variables were analyzed to evaluate their impact on insomnia risk in DR. RESULTS: Compared with the non-DR group, insomnia risk was increased in the DR [(adjusted hazard ratio (aHR): 1.125, 95% confidence interval (CI):1.108-1.142), NPDR (aHR:1.117, 95% CI:1.099-1.134), and PDR (aHR:1.205, 95% CI: 1.156-1.256), even after controlling for comorbidities, lifestyle factors, and DM-related variables. The men and youngest age groups (<40 years) were most vulnerable to insomnia risk. Sex, age, DM duration, and chronic kidney disease (CKD) status exerted interactive effects with DR status in increasing the insomnia risk. In the PDR group, sex, age, DM duration, insulin therapy status, and CKD status exerted interactive effects that increased the risk of insomnia. CONCLUSION: Insomnia risk is significantly higher in patients with DR, and clinical attention is warranted. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9333090/ /pubmed/35909567 http://dx.doi.org/10.3389/fendo.2022.939251 Text en Copyright © 2022 Um, Kim, Jeong, Hong, Seo and Han https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Um, Yoo Hyun
Kim, Tae-Won
Jeong, Jong-Hyun
Hong, Seung-Chul
Seo, Ho-Jun
Han, Kyung-Do
Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
title Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
title_full Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
title_fullStr Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
title_full_unstemmed Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
title_short Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
title_sort association between diabetic retinopathy and insomnia risk: a nationwide population-based study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333090/
https://www.ncbi.nlm.nih.gov/pubmed/35909567
http://dx.doi.org/10.3389/fendo.2022.939251
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